Hemorheological disorders in the microcirculation following hemorrhage

Issue title: Selected proceedings of the 12th European Conference on Clinical Hemorheology, 22‐26 June 2003, Sofia, Bulgaria

Article type: Research Article

Authors: Sordia, T. | Tatarishvili, J. | Varazashvili, M. | Mchedlishvili, G.

Affiliations: Microcirculation Research Center, I. Beritashvili Institute of Physiology, 14 Gotua St., 0160 Tbilisi, Georgia Tel.: +995 32 371016; Fax (Telecom Georgia): +995 32 00 11 53; E‐mail: [email protected]

Abstract: We analysed hemorheological disorders in the microcirculation of intestinal mesenterium of adult laboratory rats following massive exsanguinations when the mean arterial pressure dropped and then the hemorrhagic shock developed in the animals. The mesenteric microcirculation was analysed by the Texture Analysis System (Leitz, Wetzlar): (a) diameters of the afferent arterioles, capillaries, and efferent venules; (b) the blood flow velocity; (c) microvascular blood flow changes (during the RBC aggregation); (d) local microvascular hematocrit; and (e) the transformation of capillaries into plasmatic microvessels. During development of the hemorrhagic shock we found that the blood flow velocity decreased in all microvessels, there was an increased RBC aggregation which gradually enhanced in the mesenteric microvessels' lumen causing blood flow slowing down till appearance of stases. A part of the capillaries transformed into plasmatic vessels. Therefore the microcirculation demonstrated a significant decrease, this being related both to the lowered pressure gradient and to specific hemorheological disorders in the capillary networks.

Keywords: Hemorheological disorders, microcirculation, hemorrhage

Journal: Clinical Hemorheology and Microcirculation, vol. 30, no. 3-4, pp. 461-462, 2004