Affiliations: Thrombosis and Hemorheology Unit, La Fe University Hospital, Department of Clinical Pathology, Valencia, Spain | Endocrinology Service, Dr. Peset Hospital, Valencia, Spain | Genetic Molecular Epidemiology Unit, School of Medicine University of Valencia, Spain
Note: [] Corresponding author: Amparo Vayá, MD, PhD, Thrombosis and Hemorheology Unit, Department of Clinical Pathology, La Fe University Hospital, Avda. de Campanar, 21, 46009 Valencia, Spain. Tel.: +34 963861714; Fax: +34 961973089; E‐mail: [email protected].
Abstract: Some hemorheological parameters constitute risk factors for ischemic cardiovascular events. Most of these hemorheological factors are determined by the erythrocyte intrinsic properties and the high molecular weight plasmatic proteins, especially fibrinogen. The contribution of the plasmatic lipids to hemorheological factors is not well established. With this aim we determined hemorheological parameters in 112 healthy volunteers (62 males, 50 females) aged 35±10 years, range 19–54 years, members of our hospital staff. A complete set of rheological test was performed. Blood viscosity (BV) 230 sec−1, plasma viscosity (PV), erythrocyte aggregation index (EAI), erythrocyte elongation index (EEI), hematocrit and fibrinogen. We also determined plasmatic lipids including total cholesterol (T‐Ch) and its fractions (HDL‐Ch, LDL‐Ch, VLDL‐Ch), triglycerides, lipoproteins (Apo B, Apo A1, B/A1). Exclusion criteria were concomitant cardiovascular risk factors or any other associated pathology. Our results show a positive correlation between BV 230 sec−1 and triglycerides (r=0.335) and negative with HDL‐Ch (r=−0.451) (p=0.01), respectively; PV shows a positive correlation with T‐Ch (r=0.297), LDL‐Ch (r=0.298) and Apo B/A (r=0.290) (p=0.01). The EEI was negatively correlated with TG (p=0.05). Of all the rheological parameters evaluated, EAI is the factor which shows the highest significant correlation with plasmatic lipids: T‐Ch (r=0.515), TG (r=0.303), LDL‐Ch (r=0.507) and Apo B/A ratio (r=0.403); (p=0.01). These results suggest that plasmatic lipids contribute to modulate the blood rheological properties, slowling blood flow, favouring the development of atherothrombotics events, especially in stenotic areas or bifurcations in the vascular tree.
