Effect of different plasma expanders on erythrocyte filtrability

Article type: Research Article

Authors: Guerciolini, R. | Merante, F. | Gresele, P. | Grasselli, S. | Susani, L. | Nenci, G.G.

Affiliations: Institute of Semeiotica Medica, University of Perugia, Perugia 06100, Italy

Note: [] Accepted by: Editor T. DiPerri

Abstract: The effect of some plasma expanders (dextran 40, polygeline, succinyl-gelatin) currently used for normovolernic hemodilution (NHD) and of isotonic saline on erythrocyte deformability was tested by a whole blood filtration technique in vitro and ex vivo after NHD. Dextran 40 resulted able to improve erythrocyte filtrability ex vivo but not in vitro. Gelatine derivatives did not change ex vivo and worsened in vitro erythrocyte filtration rate. Hyperosmolarity was a major determinant of the negative influence exerted by plasma expanders on erythrocyte flexibility in vitro.

Keywords: Erythrocyte deformability, erythrocyte filtrability, normovolemic hemodilution, plasma expanders, whole blood filtration

DOI: 10.3233/CH-1986-6603

Journal: Clinical Hemorheology and Microcirculation, vol. 6, no. 6, pp. 511-521, 1986