Inhibition OF IgG-, F(ab′)₂-and myeloma protein-induced erythrocyte aggregation, by small IgG-fragments

Article type: Research Article

Authors: Imaizumi, Kazuhiko^a | Imai, Atsuko^b | Maruyama, Tohru^b | Shiga, Takeshi^a

Affiliations: [a] Department of Physiology, School of Medicine, Ehime University, Shigenobu, Onsen-gun, Ehime 791-02, Japan | [b] Division of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, Ehime 790, Japan

Note: [] Accepted by: Editor Y. Isogai

Abstract: The velocity of non-immune erythrocyte aggregation was determined by means of an automated rheoscope, consisted of an inverted microscope, a cone-plate viscometer, a TV image analyzer and a computer, in autologous plasma at a shear rate of 7.5/sec. As increasing the concentration of IgG and F(ab′)2 added to diluted plasma, the velocity of aggregation increased, resembling the accelerated aggregation in 5 cases of multiple myeloma. Fab- and Fc-fragments scarcely affected the velocity; on contrary, they inhibited the aggregation induced by IgG or F(ab′)2 as well as in multiple myeloma. As a plausible explanation of such inhibition, a competitive mechanism is suggested.

Keywords: Erythrocyte Aggregation, Multiple Myeloma, Immunoglobulin, IgG-fragments

DOI: 10.3233/CH-1984-4408

Journal: Clinical Hemorheology and Microcirculation, vol. 4, no. 4, pp. 431-439, 1984