Shear dependence of blood coagulation

Article type: Research Article

Authors: Ernst, E.^a | Matrai, A.^b | Dormandy, J.^b

Affiliations: [a] Klinik für Physikalische Medizin der Universität München, Ziemssenstr. 1, 8000 München 2 | [b] St. James’ and St. George’s Hospital, London

Note: [] Accepted by: Editor H.H. Hartert

Abstract: Although blood clotting is often referred to as shear dependent, there are little experimental data to support this. In a set of experiments fresh, non-anticoagulated blood was submitted to Couette flow. All surfaces in contact with blood had been siliconized. Samples were tested at three different shear rates i.e. shear stresses covering the physiological range. In each case clotting was detected by a 10% change of the otherwise constant reading in the x–y recorder. The results indicate a shear dependence of clotting time which decreases as shear increases.

Keywords: hemorheology, hemostasis, blood coagulation, shear forces

DOI: 10.3233/CH-1984-4403

Journal: Clinical Hemorheology and Microcirculation, vol. 4, no. 4, pp. 395-399, 1984