Affiliations: [a] Laboratoire de Biophysique, Faculté de Médecine, 74, Rue Marcel Cachin 93000 Bobigny, France | [b] Service d’Endocrinologie, Pr Sebaoun | [c] C.H.U. de Bobigny, Laboratoires Hoechst-France, Paris la Défense
Note: [] Accepted by: Editor G.A. Marcel
Abstract: A large scale study of the erythrocyte deformability in diabetes is presented. The initial filtration flow rate method is used on diluted (white blood cells reduced) RBC suspensions. The rigidity index thus obtained, IR, is largely insensitive to the filter plugging. A significant increase of IR is observed for diabetic patients (p < 0.001). This difference is probably (p < 0.05) higher for insulin dependent diabetes than for non insulin diabetes patients. A low significance (p < 0.05) negative correlation between IR and the patient’s hematocrit has been observed. No correlation has been found between the RBC rigidity increase and the following parameters:
–plasma glucose, insulin, triglycerides and cholesterol.–glycosylated hemoglobin (HbA1c), MVC, CCMH and WBC count.–presence of microangiopathic complications.
