Cholesterol induced impairment in red cell deformability and its improvement by vitamin E

Article type: Research Article

Authors: Kikuchi, Yuji | Koyama, Tomiyasu

Affiliations: Division of Physiology, Research Institute of Applied Electricity, Hokkaido University, Sapporo 060, Japan

Note: [] Accepted by: Editor Y. Isogai

Abstract: Passability of rabbit red cells through micropores (5 and 3 µm in diameter) was markedly reduced by two weeks of cholesterol feeding. In vitamin E-nicotinate administered rabbits, the pore passage times of red cells became shorter in spite of the cholesterol feeding, suggesting a positive effect of vitamin E-nicotinate on the red cell deformability impaired by hypercholesterolemia. Vitamin E-nicotinate probably modifies the interaction between red cells and plasma cholesterol.

Keywords: cholesterol, vitamin E, red cell deformability

DOI: 10.3233/CH-1983-3403

Journal: Clinical Hemorheology and Microcirculation, vol. 3, no. 4, pp. 375-382, 1983