Affiliations: [a]
Department of Anesthesiology, Kaifeng 155 Hospital, China RongTong Medical Healthcare Group Co. Ltd., Kaifeng, Henan, China
| [b]
Department of Cardiology, Kaifeng Central Hospital, Kaifeng, Henan, China
Correspondence:
[*]
Corresponding author: Jie-Yun Liu, Department of Cardiology, Kaifeng City Central hospital, No. 85, of Hedao Street, Longting District, Kaifeng 475000, Henan Province, China. Tel.: +86 13271597920; E-mail: [email protected].
Note: [1] These authors contributed equally to this study.
Abstract: OBJECTIVE:The aim of this study is to investigate the correlation between the triglyceride-glucose-body mass index (TyG-BMI) and the characteristics of various carotid plaques in middle-aged and elderly patients with acute myocardial infarction (AMI). METHODS:A retrospective study was conducted on 380 patients with AMI hospitalized in the Cardiology Department of Kaifeng Central Hospital. Based on carotid ultrasound results, patients were divided into the following two groups: the stable plaque group and the unstable plaque group. Additionally, a control group comprising 380 healthy individuals visiting the hospital’s physical examination center during the same timeframe was established. Fasting venous blood samples were collected from all participants to measure blood glucose and triglyceride. The baseline TyG-BMI index was calculated using the formula Ln [fasting triglyceride (mg/dL)×fasting blood glucose (mg/dL)/2]×BMI. The correlation between different plaque groups and the TyG-BMI index was analyzed. RESULTS:The TyG-BMI index was significantly higher in the unstable plaque group compared to the stable plaque group, with values of 252.81±29.99 and 201.92±28.72, respectively (P = 0.034). Spearman’s correlation analysis showed a positive correlation between the instability of carotid plaques and the TyG-BMI index in patients with AMI (r = 0.521, P = 0.003). Logistic regression analysis indicated that the TyG-BMI index was an important risk factor for unstable carotid plaques in patients with AMI (OR = 2.691, 95% CI: 1.169–4.123). CONCLUSION:The findings of this study suggest that an elevated TyG-BMI index significantly increases the risk of unstable carotid plaques in patients with AMI, making it an important risk factor for carotid plaque instability.
