Which sub-compartments of fat mass and fat-free mass are related to blood viscosity factors?

Issue title: Selected articles from the 3rd Joint Meeting of The European Society for Clinical Hemorheology and Microcirculation (ESCHM) , The International Society for Clinical Hemorheology (ISCH) and The International Society of Biorheology (ISB), Regensburg, Germany, 28 – 30 September 2023

Guest editors: L. Prantl, A. Krueger-Genge and F. Jung

Article type: Research Article

Authors: Brun, Jean-Frédéric^{a; b; *} | Varlet-Marie, Emmanuelle^{c; d} | Myzia, Justine^{a; b} | Vachoud, Laurent^d | Marion, Bénédicte^c | Roques, Céline^c | Raynaud de Mauverger, Eric^{a; b} | Mercier, Jacques^{a; b}

Affiliations: [a] Department of Endocrinology and U1046 INSERM, UMR 9214 CNRS “Physiopathologie & Médecine Expérimentale du Cœur et des Muscles - PHYMEDEXP”, Unité d’Explorations Métaboliques (CERAMM), Université de Montpellier, Montpellier, France | [b] Département de Physiologie Clinique, Hôpital Lapeyronie CHRU Montpellier, Montpellier, France | [c] Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS, Ecole Nationale Supérieure de Chimie de Montpellier, Université de MontpellierMontpellier, France | [d] UMR QualiSud, Faculté de Pharmacie, Université de Montpellier, Montpellier, France

Correspondence: [*] Corresponding author: Jean-Frédéric Brun, Department of Endocrinology and U1046 INSERM, UMR 9214 CNRS “Physiopathologie & Médecine Expérimentale du Cœur et des Muscles - PHYMEDEXP”, Unité d’Explorations Métaboliques (CERAMM), Université de Montpellier, Département de Physiologie Clinique, Hôpital Lapeyronie CHRU Montpellier, France. E-mail: [email protected].

Abstract: The size of body compartments is a determinant of several factors of blood viscosity. Red cell aggregation is proportional to fat mass while hematocrit is proportional to both fat-free mass and abdominal adiposity, but which parts of these body components are involved in this relationship is not known. Segmental bioelectrical impedance analysis (sBIA) provides a possibility to delineate the relationships more precisely between various subdivisions of the body and blood viscosity factors, going farther than preceding studies using non segmental BIA. In this study we investigated in 38 subjects undergoing a standardized breakfast test with mathematical modelling of glucose homeostasis and a segmental bioelectrical impedance analysis (sBIA) the relationships between the various compartments of the body and viscosity factors. Blood and plasma viscosity were measured with the Anton Paar rheometer and analyzed with Quemada’s model. The parameters better correlated to hematocrit are fat free mass (r = 0.562) and its two components muscle mass (r = 0.516) and non-muscular fat-free mass (r = 0.452), and also trunk fat mass (r = 0.383) and waist-to hip ratio (r = 0.394). Red cell aggregation measurements were correlated with both truncal and appendicular fat mass (r ranging between 0.603 and 0.728). Weaker correlations of M and M1 are found with waist circumference and hip circumference. This study shows that the correlation between lean mass and hematocrit involves both muscle and non-muscle moieties of lean mass, and that both central and appendicular fat are determinants of red cell aggregation.

Keywords: Fat mass, fat-free mass, muscle, red cell, viscosity, hemorheology

DOI: 10.3233/CH-238118

Journal: Clinical Hemorheology and Microcirculation, vol. 86, no. 1-2, pp. 245-252, 2024