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Article type: Research Article
Authors: Cucuruz, B.a; b; e; * | Kopp, R.c | Hampe-Hecht, H.b | Andercou, O.d | Schierling, W.e | Pfister, K.e | Koller, M.f | Noppeney, T.b
Affiliations: [a] Department of Radiology, University Hospital Halle, Halle, Germany | [b] Department of Vascular Surgery, Martha Maria Hospital Nuremberg, Nuremberg, Germany | [c] Department of Vascular Surgery, University Hospital Zürich, Zürich, Switzerland | [d] Department of Surgery, University Hospital Cluj, Cluj, Romania | [e] Department of Vascular Surgery, University Hospital Regensburg, Regensburg, Germany | [f] Center for Clinical Studies, University Hospital Regensburg, Regensburg, Germany
Correspondence: [*] Corresponding author: Cucuruz Beatrix, Department of Radiology, University Hospital Halle, Ernst-Grube-Straße 40, 06120 Halle (Saale), Germany. Tel.: +49 345 557 2441; Fax: +49 345 557 2157; E-mail: [email protected].
Abstract: BACKGROUND:Neuromodulation is a therapeutic option to improve limb salvage in end-stage peripheral arterial disease (PAD), but there is no consensus on its indication for spinal cord stimulation (SCS) in PAD patients. OBJECTIVE:The aim of this study was to present the outcome of end-stage PAD patients treated with SCS. METHODS:This study is a retrospective analysis based on a local prospective registry. Neuromodulation was performed if there was: 1) no revascularisation option, 2) no septicemia, 3) and Rutherford stage 4–6. The primary endpoint of the study was limb salvage. Secondary endpoints were reduction in pain or simply pain reduction pain (assessed using a visual anlog scale/VAS) and improvement in walking distance. RESULTS:Limb salvage was reached in 30/34 patients (88%). Patients reported a significant reduction in pain on the 10-point VAS scale from baseline (median = 7.5, IQR = 7–8) to follow-up at 2 years (median = 0, IQR 0–2.75), p < 0.001. Walking distance also improved from preoperative (median = 50 m, IQR = 20–50 m) to follow-up at 2 years (median = 150 m, IQR 50–272 m), p < 0.001. RESULTS:SCS implantation in patients with end-stage PAD can enable limb salvage in a high percentage of cases and increase mobility due to pain reduction. The role of microcirculation in these improvements needs to be investigated in further studies.
Keywords: Neuromodulation, spinal cord stimulation, end-stage peripheral artery disease, chronic critical limb ischemia
DOI: 10.3233/CH-221436
Journal: Clinical Hemorheology and Microcirculation, vol. 81, no. 4, pp. 315-324, 2022
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