Sublingual microcirculatory alterations during the immediate and early postoperative period: A systematic review and meta-analysis

Article type: Research Article

Authors: Chalkias, Athanasios^{a; b; *} | Papagiannakis, Nikolaos^c | Mavrovounis, Georgios^d | Kolonia, Konstantina^a | Mermiri, Maria^a | Pantazopoulos, Ioannis^d | Laou, Eleni^a | Arnaoutoglou, Eleni^a

Affiliations: [a] Department of Anesthesiology, Faculty of Medicine, University of Thessaly, Larisa, Greece | [b] Outcomes Research Consortium, Cleveland, OH, USA | [c] First Department of Neurology, National and Kapodistrian University of Athens, Medical School, Athens, Greece | [d] Department of Emergency Medicine, Faculty of Medicine, University of Thessaly, Larisa, Greece

Correspondence: [*] Corresponding author: Athanasios Chalkias, Department of Anesthesiology, University Hospital of Larisa, C’ Wing, 2nd Floor, PC 41110, Mezourlo, Larisa, Greece. Tel.: +30 2413502953; Fax.: +30 2413501017; E-mail: [email protected].

Abstract: BACKGROUND: The incidence of postoperative microcirculatory flow alterations and their effect on outcome have not been studied extensively. OBJECTIVE: This systematic review and meta-analysis were designed to investigate the presence of sublingual microcirculatory flow alterations during the immediate and early postoperative period and their correlation with complications and survival. METHODS: A systematic search of PubMed, Scopus, Embase, PubMed Central, and Google Scholar was conducted for relevant articles from January 2000 to March 2021. Eligibility criteria were randomized controlled and non-randomized trials. Case reports, case series, review papers, animal studies and non-English literature were excluded. The primary outcome was the assessment of sublingual microcirculatory alterations during the immediate and early postoperative period in adult patients undergoing surgery. Risk of bias was assessed with the Ottawa-Newcastle scale. Standard meta-analysis methods (random-effects models) were used to assess the difference in microcirculation variables. RESULTS: Thirteen studies were included. No statistically significant difference was found between preoperative and postoperative total vessel density (p = 0.084; Standardized Mean Difference (SMD): –0.029; 95%CI: –0.31 to 0.26; I2 = 22.55%). Perfused vessel density significantly decreased postoperatively (p = 0.035; SMD: 0.344; 95%CI: 0.02 to 0.66; I2 = 65.66%), while perfused boundary region significantly increased postoperatively (p = 0.031; SMD: –0.415; 95%CI: –0.79 to –0.03; I2 = 37.21%). Microvascular flow index significantly decreased postoperatively (p = 0.028; SMD: 0.587; 95%CI: 0.06 to 1.11; I2 = 86.09%), while no statistically significant difference was found between preoperative and postoperative proportion of perfused vessels (p = 0.089; SMD: 0.53; 95%CI: –0.08 to 1.14; I2 = 70.71%). The results of the non-cardiac surgery post-hoc analysis were comparable except that no statistically significant difference in perfused vessel density was found (p = 0.69; SMD: 0.07; 95%CI: –0.26 to 0.39; I2 = 0%). LIMITATIONS: The included studies investigate heterogeneous groups of surgical patients. There were no randomized controlled trials. CONCLUSIONS: Significant sublingual microcirculatory flow alterations are present during the immediate and early postoperative period. Further research is required to estimate the correlation of sublingual microcirculatory flow impairment with complications and survival.

Keywords: Complications, hemodynamics, microcirculation, perfusion, postoperative, surgery

DOI: 10.3233/CH-211214

Journal: Clinical Hemorheology and Microcirculation, vol. 80, no. 3, pp. 253-265, 2022