Efficacy of repeated intravenous tranexamic acid in reducing perioperative bleeding of acetabular fractures

Article type: Research Article

Authors: Xu, Chen^a | Wu, Min^b | Wang, Zhaodong^b | Liu, Yajun^b | Zhou, Pinghui^b | Guan, Jianzhong^{a; b; *}

Affiliations: [a] Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China | [b] Department of Orthopedics, Bengbu Medical University Affiliated to First Hospital, Bengbu, Anhui Province, China

Correspondence: [*] Corresponding author: Jianzhong Guan, Department of Orthopedics, Bengbu Medical University Affiliated to First Hospital, No. 287, Chang Huai Street, Long Zi River District, Bengbu 233000, AnHui province, China. Tel.: +86 13955231199; E-mail: [email protected].

Abstract: BACKGROUND:Application of tranexamic acid (TXA) in the treatment of acetabular fractures could reduce intraoperative and postoperative blood loss. OBJECTIVE:To investigate the effect of single and repeated intravenous infusion of TXA on blood loss of acetabular fractures. METHODS:120 patients with acetabular fractures admitted to our hospital from January 2017 to September 2020 were retrospectively divided into three groups: Patients accepted 1g TXA at preoperative 30 minutes were defined as single TXA group (n = 40); Patients accepted 1g TXA at preoperative 30 minutes and 1g TXA at 3 hours after the start of surgery were defined as repeated TXA group (n = 40); Patients accepted normal saline at preoperative 30 minutes were defined as control group (n = 40). RESULTS:The total blood loss in single TXA group and repeated TXA group were significantly lower than control group, and the total blood loss in the repeated TXA group was significantly lower than single TXA group (P < 0.05). The hidden blood loss from surgery to postoperative 1 day in repeated TXA group was significantly lower than single TXA group and the control group(P < 0.05). No significant differences were observed in the operative time, postoperative transfusion rate and thrombosis rate among the three groups (P >  0.05). CONCLUSION:Repeated TXA is more recommended during acetabular fracture surgery since it can reduce the total blood loss without increasing the operative time, postoperative transfusion rate and thrombosis rate compared with single TXA.

Keywords: Tranexamic acid, acetabular fracture, single TXA infusion, repeated TXA infusion, total blood loss, thrombosis rate

DOI: 10.3233/CH-211203

Journal: Clinical Hemorheology and Microcirculation, vol. 79, no. 4, pp. 567-573, 2021