Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells
Issue title: Selected papers of the 39th Conference of the German Society for Clinical Microcirculation and Hemorheology, 6-7 November 2020, Hannover, Germany
Guest editors: B. Hiebl, A. Krüger-Genge and F. Jung
Affiliations: [a] Fraunhofer-Institute for Applied Polymer Research (IAP), Potsdam-Golm, Germany
| [b] Institute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology, Senftenberg, Germany
| [c] Institute for Microbiology and Virology, Medizinische Hochschule Brandenburg Theodor Fontane, Senftenberg, Germany
| [d] Department of Radiology and Interdisciplinary Ultrasound Department, University Hospital Regensburg, Regensburg, Germany
Correspondence:
[*]
Corresponding author: Dr. A. Krüger-Genge, Fraunhofer Institute for Applied Polymer Research (IAP), Potsdam-Golm, Germany. E-mail: [email protected].
Note: [1] Both authors contributed equally to the work.
Abstract: Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.
