Affiliations: Dipartimento Biomedico di Medicina Interna e Specialistica, Universitá di Palermo, Italy
Correspondence:
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Corresponding author: Gregorio Caimi, Dipartimento Biomedico di Medicina Interna e Specialistica, Universitá degli Studi di Palermo, Via del vespro 129, 90100 Palermo, Italy. Tel.: +39 091 6554406; Fax: +39 091 6554535; E-mail: [email protected].
Abstract: Considering that obstructive sleep apnea syndrome (OSAS) is usually associated with endothelial dysfunction, atherosclerosis and cardiovascular disorders, our aim was to examine the erythrocyte deformability and the oxidative status in a group of OSAS subjects. We consecutively enrolled 48 subjects with OSAS defined after a 1-night cardiorespiratory sleep study, subsequently subdivided according to the apnea/hypopnea index (AHI) value in two subgroups: Low (L = 21 subjects with AHI<30) and High (H = 27 subjects with AHI>30). We evaluated the erythrocyte deformability, expressed as elongation index (EI) and the parameters of the oxidative status, such as lipid peroxidation (expressed as thiobarbituric acid-reactive substances – TBARS) and protein oxidation (measured as carbonyl groups – PC). In the entire group and in the two subgroups of OSAS subjects we found a decreased erytrocyte deformability at all shear stresses, not correlated with the plasmatic oxidative stress nor with the polysomnographic parameters. Lipid peroxidation was increased in the whole group and in the H subgroup of OSAS while protein oxidation showed a different trend. As in OSAS the osmotic fragility and the metabolism of the red cells seem to be not impaired, the oxidative damage to the red cell membrane proteins might be responsible for the reduced erythrocyte deformability. This rheological alteration, in addition to the increase in whole blood and plasma viscosity and to the erythrocyte hyperaggregation, could influence the microcircolatory profile in OSAS subjects.
Keywords: Erythrocyte deformability, lipid peroxidation, protein oxidation, OSAS
