The value of dynamic contrast enhanced ultrasound (DCE-US) in monitoring treatment effect of high-intensity focused ultrasound (HIFU) in locally advanced pancreatic cancer (LAPC)

Article type: Research Article

Authors: Zuo, Dan^{a; b; 1} | Feng, Yi^{c; 1} | Zhang, Qi^a | Qiu, Yi-Jie^a | Tian, Xiao-Fan^a | Shi, Shuai-Nan^a | Dong, Yi^{a; b; *} | Liu, Tian-Shu^c | Wang, Wen-Ping^{a; b}

Affiliations: [a] Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China | [b] Shanghai Institute of Medical Imaging, Shanghai, China | [c] Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China

Correspondence: [*] Corresponding author: Prof. Dr. med. Yi Dong, Department of Ultrasound, Zhongshan Hospital, Fudan University, 200032 Shanghai, China. Tel.: +86 21 64041990; E-mail: [email protected].

Note: [1] Share the co-first authorship.

Abstract: PURPOSE:To evaluate the feasibility of dynamic contrast enhanced ultrasound (DCE-US) in predicting treatment response of high-intensity focused ultrasound (HIFU) in patients with locally advanced pancreatic cancer (LAPC) lesions. PATIENTS AND METHODS:In this prospective study, 10 patients with pathologically confirmed LAPC lesions (7 men, 3 women; average age, 61.13±5.80 years) were prospectively enrolled. All patients received HIFU treatment with peak intensity at 12000 W/cm2. Contrast enhanced ultrasound (CEUS) was performed with an ACUSON Oxana 2 ultrasound equipment and a 6 C-1 transducer (1–6 Hz). A dose of 2.4 ml SonoVue was injected for each examination. Time intensity curves (TICs) were generated and quantitative analyses were performed by SonoLiver software. B mode ultrasound (BMUS) features, CEUS enhancement patterns, TICs, CEUS quantitative parameters and serum carcinoma antigen 19-9 (CA19-9) levels were compared before and 4 weeks after HIFU treatment. Statistical analyses were performed with SPSS Version 20.0 and GraphPad Prism 5. RESULTS:While comparing before and after HIFU, no significant difference was obtained on mean size of lesion, BMUS or CEUS features. After HIFU treatment, TICs showed decreased and delayed enhancement. Among all CEUS quantitative parameters, significant decrease could be found in maximum intensity (MI) (60.66±23.95% vs 41.31±26.74%) and mean transit time (mTT) (76.66±47.61 s vs 38.42±28.35 s). CA19-9 level decreased significantly after HIFU (2747.92±4237.41 U/ml vs 715.08±1773.90 U/ml) (P = 0.05). CONCLUSION:DCE-US combining with quantitative analysis might be a useful imaging method for early treatment response evaluation of HIFU in LAPC lesions.

Keywords: Dynamic contrast enhanced ultrasound (DCE-US), locally advanced pancreatic cancer (LAPC), high-intensity focused ultrasound (HIFU), therapeutic response, blood perfusion

DOI: 10.3233/CH-201020

Journal: Clinical Hemorheology and Microcirculation, vol. 77, no. 3, pp. 323-333, 2021