Effect of vinca alkaloids on human erythrocyte aggregation

Article type: Research Article

Authors: Sabio, Hernan

Affiliations: Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908

Note: [] Accepted by: Editor G.Y.F. Seaman

Abstract: The relative effects of three vinca alkaloids on the erythrocyte surface were assessed by evaluating erythrocyte aggregation. The time required for aggregation and the rate of sedimentation of formed aggregates was quantitated in systems utilizing Dextran, polybrene, and an antibody as the aggregation inducers. Vinca alkaloid inhibition of erythrocyte aggregation was demonstrated which appears to be concentration dependent. Vinblastine was more inhibitory than Vindesine or Vincristine. Scanning electron microscopy suggests that decreased deformability is a factor in vinca alkaloid inhibition of erythrocyte aggregation.

Keywords: Erythrocyte, aggregation, vinca alkaloid, vincristine, vinblastine, vindesine

DOI: 10.3233/CH-1982-2306

Journal: Clinical Hemorheology and Microcirculation, vol. 2, no. 3, pp. 219-227, 1982