Affiliations: [a] Cardiology Service, Insular-Materno Infantil University Hospital, Las Palmas de Gran Canaria, Spain
| [b] Medical and Surgical Sciences Department, Faculty of Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
| [c] Department of Biochemistry and Clinical Analyses, Insular-Materno Infantil University Hospital, Las Palmas de Gran Canaria, Spain
| [d] Ophthalmology Service, Dr. Negrín University Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain
Correspondence:
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Corresponding author: Efrén Martínez-Quintana, Servicio de Cardiología. Complejo Hospitalario Universitario Insular Materno Infantil. Avd. Marítima del Sur s/n. 35016 Las Palmas de Gran Canaria. Spain. E-mail: [email protected].
Abstract: BACKGROUND:Platelet activation is linked with thrombosis, inflammation or heart failure. OBJECTIVE:To establish clinical and analytical factors that may favor high mean platelet volume (MPV) and to determine if MPV levels favor major adverse cardiovascular events (MACE). METHODS:Stable CHD patients and a control population matched for age, sex and cardiovascular factors. RESULTS:658 CHD patients and 2092 controls were studied. Median age in CHD patients was 33 (25–41) year old with 56% of them being male. No significant differences were seen between MPV values and cardiac complexity (p = 0.308) nor between MPV values in the CHD and control groups (p = 0.911). CHD patients had significant lower platelet count and MPV levels than patients in the control group. In the binary logistic regression analysis NT-pro-BNP levels above 125 pg/ml, thrombocytopenia and having atrial fibrillation/flutter reached statistical significance as predictors of MPV levels above 11 fL. The Kaplan-Meier survival analysis showed no significance between MPV levels higher than 11 fL and MACE, cardiovascular mortality and thrombotic events in a median time follow-up of 6.7(1.5–10.6) years. CONCLUSIONS:Atrial fibrillation/flutter, heart failure and thrombocytopenia are predictors of high MPV levels. A MPV above 11 fL is not associated with MACE at a median follow-up time.
Keywords: Mean platelet volume, inflammation, heart failure, congenital heart disease
