Affiliations: [a] Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
| [b] Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
| [c] Department of Dermatology, University of California Davis School of Medicine, Sacramento, USA
| [d] National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County, Taiwan
| [e] Department of Dermatology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
| [f] Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
Correspondence:
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Corresponding author: Chih-Hung Lee, Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Dapi Rd, Kaohsiung 83301, Kaohsiung, Taiwan. Tel.: +886 7 7317123/Ext. 2299; Fax: +886 7 7337612; E-mail: [email protected].
Abstract: Background:Skin physiology measurement is receiving more attention for detecting vasculopathy in systemic sclerosis (SSc). Laser Doppler flowmetry (LDF) is a widely used physiological measurement to assess cutaneous microcirculation. However, findings of LDF may be subtle during early stage of microangiopathy in SSc. Objective:We hypothesized that cold stress test combined with LDF could detect early-stage microangiopathy in patients with SSc. Methods:A 67-year-old male came with multiple ulcerations on his fingers for one year. After excluding diseases such as diabetes mellitus-related peripheral arterial occlusive disease and smoking-related Buerger’s disease, the diagnosis of SSc was made according to the 2013 ACR/EULAR criteria. We performed LDF and angiography for a patient with SSc and compared the results. Results:Although occlusions of right ulnar and digital arteries were obvious in angiography, the baseline skin temperature and perfusion unit on right fingers remained within normal limits. While the microcirculatory abnormalities measured by LDF alone are subtle, LDF combined with cold stress test detected a significant slow recovery of skin blood flow 40 minutes after cold immersion. Conclusions:In conclusion, there may be discordance between macrovasculopathy and baseline microcirculatory blood flow in SSc. In such a case, cold immersion test is essential to measure the dynamic change and slow recovery of blood flow.
