Affiliations: [a] Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, Catanzaro, Italy
| [b] Department of Experimental Medicine and Surgery, Tor Vergata University, Rome, Italy
| [c] Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy
| [d] Department of Health Science, Magna Græcia University of Catanzaro, Catanzaro, Italy
Correspondence:
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Corresponding author: Agostino Gnasso, Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, Viale Europa 88100 Catanzaro, Italy. Tel.: +3909613697039; Fax: +3909613647250; E-mail: [email protected].
Abstract: BACKGROUND:Blood viscosity (BV) might influence glucose delivery to peripheral tissues and play an important role in insulin resistance and diabetes mellitus. However, the exact relationship between BV and insulin resistance is not yet clear. OBJECTIVES:Aim of the present study is to evaluate the effects of the acute reduction in BV on insulin resistance, in healthy male subjects. METHODS:Fifteen healthy male blood donors have been studied before and 48 hours after blood donation. Blood and plasma viscosity have been measured at 37°C with a cone-plate viscometer. Insulin resistance has been evaluated by euglycemic/hyperinsulinemic clamp in eight subjects, and by iHOMA2 Index in further seven subjects. RESULTS:Blood viscosity was markedly reduced after blood donation (BV225 (cP) 4.53 ± 0.59 vs. 4.18 ± 0.31, p < 0.05). Insulin resistance was unchanged: MFFM clamp: 5.6 ± 4.5vs. 4.4 ± 2.2 and iHOMA2 Index 1.2 ± 0.6 vs. 1.2 ± 0.5, before vs. after respectively, p = NS. Blood pressure and lipids were unchanged after blood donation. CONCLUSIONS:The present results demonstrate that acute reduction of BV in healthy male subjects does not change the insulin resistance, measured using both euglycemic/hyperinsulinemic clamp and iHOMA2 Index. Further intervention studies are needed to assess the effect that the reduction in BV can have in subjects with insulin resistance.
