Issue title: Selected Presentations held at the 35th Conference of the German Society for Clinical Microcirculation and Hemorheology, Mainz, Germany, 4-5 November, 2016
Guest editors: F. Jung and T. Gori
Article type: Research Article
Authors: Lamby, P.a; * | Jung, F.b | Falter, J.a | Mrowietz, C.c | Graf, S.a | Schellenberg, L.d | Platz Batista da Silva, N.e | Prantl, L.a | Franke, R.P.f | Jung, E.M.d
Affiliations:
[a] Department of Plastic and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany
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[b]
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany
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[c]
Institute for Heart and Circulation Research, Eißendorfer Pferdeweg, Hamburg-Harburg, Germany
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[d] Department of Anesthesiology, University of Regensburg, Regensburg, Germany
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[e] Department of Radiology, University Hospital Regensburg, Regensburg, Germany
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[f] Department of Biomaterials, Central Institute for Biomedical Engineering, University of Ulm, Ulm, Germany
Correspondence:
[*]
Corresponding author: P. Lamby, Department of Plastic and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany. Tel.: +49 941 944 6763; Fax: +49 941 944 6948; E-mails: [email protected]; [email protected].
Abstract: BACKGROUND: Intra-arterial administration of radiographic contrast media (CM) is discussed to impair renal perfusion. The pathogenesis of contrast-induced Nephropathy (CIN) is still not clarified. OBJECTIVE: This trial was performed to prove the effects of two CM with different molecular structure on renal perfusion. METHODS: A prospective, randomized study on 16 pigs was designed to compare the outcome after application of a low-osmolar iodinated CM (770 mOsm/kg H2O – Group1) and an iso-osmolar iodinated CM (290 mOsm/kg H2o – Group2). Color Coded Doppler Sonography (LOGIQ E9, GE, Milwaukee, USA) was applied for measuring the Renal Resistive Index (RRI) before and after the first, fifth, and tenth bolus of CM. Statistics was performed using analysis of variance for repeated measurements with the Factor “CM”. RESULTS: All flow spectra were documented free of artifacts and Peak Systolic Velocity (PSV), Enddiastolic Velocity (EDV) and RRI respectively could be calculated. Mean PSV in Group 1 led to a decrease while in Group 2 PSV showed a significant increase after CM (p = 0,042). The course of the mean EDV in both groups deferred accordingly (p = 0,033). Mean RRI over time significantly deferred in both groups (p = 0,001). It showed a biphasic course in Group 2 and a decrease over time in Group 2. CONCLUSION: While iso-osmolar CM induced an increase of PSV and EDV together with a decrease of RRI, low-osmolar CM could not show this effect or rather led to the opposite.
Keywords: Renal perfusion, radiographic contrast media, contrast agent, CCDS, color coded Doppler sonography, contrast-induced Nephropathy, CIN
DOI: 10.3233/CH-168110
Journal: Clinical Hemorheology and Microcirculation, vol. 64, no. 3, pp. 287-295, 2016
Published: 21 January 2017
