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Skin microvascular morphology and hemodynamics during treatment with veno-arterial extra-corporeal membrane oxygenation

Article type: Research Article

Authors: Wester, Torjus; | Awan, Zaheer Ahmed; | Kvernebo, Tobias Skylstad; | Salerud, Göran | Kvernebo, Knut;

Affiliations: Circulation laboratory, Department of Cardio-thoracic Surgery, Oslo University Hospital, Ullevaal, Norway | Medical Faculty, University of Oslo, Norway | Volvat Medical Centre, Oslo, Norway | Institute of Biomedical Engineering, Linköping Univeristy, Sweden

Note: [] Corresponding author: Torjus Wester, Oslo University Hospital, Kirkeveien177, 0450 Oslo, Norway. Tel.: +47 22 11 91 34; Fax: +47 22 11 74 70; E-mail: [email protected] Present address: Department of Plastic and Recontructive surgery, Oslo University Hospital.

Keywords: Capillary flow heterogeneity, capillary pathology, cardiogenic shock, extra-corporeal life support, extra-corporeal membrane oxygenation, microvascular hemodynamics, microvascular monitoring, vital microscopy

DOI: 10.3233/CH-131670

Journal: Clinical Hemorheology and Microcirculation, vol. 56, no. 2, pp. 119-131, 2014

Published: 2014
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Abstract

Objectives: To explore the potentials of microcirculatory assessments for predicting outcome of patients treated with extra corporeal membrane oxygenation for cardiogenic shock. Methods: Eight patients with acute cardiogenic shock treated with ECMO and eight healthy controls were examined with skin vital microscopy and laser Doppler perfusion measurements. Results: Three patients died on ECMO (group 1). Five patients were successfully weaned off ECMO (group 2). Four patients were discharged from hospital and one died after successful weaning from bleeding complications. Patients surviving ECMO (group 2) had microcirculatory findings comparable with healthy controls. Patients in group 1 showed major skin microvascular pathology: pericapillary bleedings (n = 1), pericapillary dark haloes (n = 2) and capillary micro thrombi (n = 1). As compared with survivors they had lower functional capillary density (FCD) (n = 3), higher heterogeneity of functional capillary density (n = 3) and significantly reduced capillary mean flow-categorical velocity (n = 2). Laser Doppler measurements in group 1 had non-significant lower laser Doppler flux values as compared with survivors and controls. Conclusion: Skin microvascular pathology as detected with video microscopy (pericapillary bleedings or haloes, micro-thrombi/capillaries with “no flow”, low FCD with high spatial distribution heterogeneity or low mean flow-categorial velocity) seems to be associated with poor prognosis.

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