Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Langer, R. | Rossmanith, K. | Henrich, H.A.
Affiliations: Chirurgische Universitatsklinik, Experimentelle Chirurgie, 97080 Wiirzburg, Germany
Abstract: The action of prostaglandins on the vascular smooth muscle but not on the blood itself is well established. The present study evaluates possible effects of the prostaglandins (PGs) D2, E1, E2, F1α, F2α and of the I2 analogue Iloprost®on blood flow properties. To get insight mto the mode of action of the compounds their effects on different hemorheological parameters were measured under physiological conditions. In no case an effect on plasma viscosity could be seen; in the presence of PG D2, F1α and F2α no effect at all was observerd. With PG E2, however, the erythrocyte filtrability and the elastic component of the visco-elasticity decreased, while the erythrocyte aggregation increased. The opposite was seen as well in whole blood, run with PG E1, as in platelet- and leucocyte-depleted blood, run with Iloprost®. A similar or identic side of action is assumed for the effective compounds. Noteworthly these agents did not show typical sigmoid shaped dose-efficacy dependencies. They rather exerted their hemorheological actions with the extraordinary low doses of 10−11 resp. 10−9 mol/l and were effective over a concentration range of 2 - 3 decimal places only. The over all subtle effects utmostly were deviations of the controls about 5 - 10 %. These features are suggestive of semaphores without any therepeutic actions on the erythrocyte fluidity.
Keywords: Prostaglandins, IloprostR, erythrocytes, aggregation, deform ability
DOI: 10.3233/CH-1995-15604
Journal: Clinical Hemorheology and Microcirculation, vol. 15, no. 6, pp. 829-839, 1995
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]