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Issue title: Selected Proceedings of the 16th Conference of the European Society for Clinical Hemorheology and Microcirculation (ESCHM), 18–21 June, 2011, Munich, Germany
Article type: Research Article
Authors: Simmonds, Michael J. | Tripette, Julien; ; | Sabapathy, Surendran | Marshall-Gradisnik, Sonya M. | Connes, Philippe;
Affiliations: Faculty of Health Sciences and Medicine, Bond University, QLD, Australia | UPRES EA (ACTES), Université des Antilles et de la Guyane, Campus de Fouillole, Guadeloupe | UMR Inserm, CHU de Pointe a'Pitre, Guadeloupe | Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital, Canada | School of Physiotherapy and Exercise Science, Griffith University, QLD, Australia
Note: [] Corresponding author: Michael J. Simmonds, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia. Tel.: +61 (0) 7 5595 4463; Fax: +61 (0) 7 5595 4122; Email: [email protected]
Abstract: Background: The principal determinants of oxygen uptake ($\Vdot$O2) kinetics are controversial, with dynamic changes in central and peripheral factors mediating oxygen supply and utilisation suggested to be limiting. The aim of this study was to determine whether important parameters of blood rheology were related to the exercise-induced time-course changes in $\Vdot$O2 and cardiac output ($\Qdot$c), or steady-state arteriovenous oxygen difference (a-vO2D) during submaximal cycling. Methods and Results: Blood was collected from ten healthy, recreationally active males and females (age: 21.7 ± 1.3 yr; body mass index: 22.7 ± 2.0 kg·m−2), before each subject cycled at 105% of the first ventilatory threshold. Red blood cell aggregation was negatively correlated with steady-state $\Vdot$O2 during exercise and the a-vO2D at rest (r = −0.73, p < 0.05), and positively correlated to $\Qdot$c at rest (r = 0.71, p < 0.05). Blood viscosity at various shear rates was negatively correlated with the time constant of $\Vdot$O2 (all p < 0.01) on-transient kinetics. Red blood cell deformability at various shear stress was positively correlated to the time constant of $\Vdot$O2 (all p < 0.05) on-transient kinetics. Conclusions: The findings of the present study suggest that the rheological properties of blood may modulate, at least in part, the rate of change in the uptake and/or utilisation of oxygen at the onset of exercise.
Keywords: Aggregation, blood viscosity, deformability, oxygen uptake kinetics, red blood cell
DOI: 10.3233/CH-2011-1473
Journal: Clinical Hemorheology and Microcirculation, vol. 49, no. 1-4, pp. 231-241, 2011
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