Hematological and hemorheological changes in rats with biliary cirrhosis

Article type: Research Article

Authors: Fischer, Gottfried | Schlappritzi, Evelyn | Reinhart, Walter H.

Affiliations: Department of Clinical Pharmacology, Inselspital, University of Berne, Switzerland | Department of Internal Medicine, Inselspital, University of Berne, Switzerland

Abstract: Hematological and hemorheological changes were investigated in rats with secondary biliary cirrhosis, induced by bile duct ligation. 5 weeks after the ligation secondary biliary cirrhosis was accompanied by macrocytic anemia, reticulocytosis, and leukocytosis. Plasma viscosity was unchanged while whole blood viscosity was decreased because of the low hematocrit. Erythrocyte deformability as assessed by filtration was unchanged. A one week treatment with S-adenosylmethionine had no influence.

Keywords: Biliary cirrhosis, Erythrocyte deformability, Blood viscosity, Anemia, S-adenosylmethionine

DOI: 10.3233/CH-1993-13408

Journal: Clinical Hemorheology and Microcirculation, vol. 13, no. 4, pp. 491-499, 1993