Affiliations: Unité de Biorhéologie, Université Paris 6 et CNRS URA 343, CHU Pitié-Salpêtrière, Paris, FRANCE | Laboratoire de Physiologie de la Motricité, Université Paris 6 et CNRS URA 385, CHU Pitié-Salpêtrière, Paris, FRANCE | Hôpital Henri Mondor, INSERM U 91, Créteil, FRANCE
Abstract: A viscometric study including measurements in static and dynamic flow conditions has been carried out on fractionated sickle blood separated into light and dense fractions studied in both oxygenated and deoxygenated states. The results, compared to those obtained from control blood at the same hematocrit, show : - for the oxygenated light cell fraction a decreased red blood cell (RBC) disaggregation due to plasma viscosity increase, for the oxygenated dense fraction a modified RBC aggregation due to both membrane cell alterations and plasma viscosity increase, - for both light and dense fractions in deoxygenated state, a loss of RBC aggregation which abolishes dynamic rheological properties (thixotropy and viscoelasticity) in relationship with the presence of polymerized hemoglobin.
