The importance of rheological parameters in the therapy of microcirculatory disorders

Article type: Research Article

Authors: Bláha, M. | Rencová, E. | Bláha, V.^; | Malý, R. | Blažek, M. | Studnička, J. | Andrýs, C. | Fátorová, I. | Filip, S. | Kašparová, M. | Procházková, R. | Malý, J. | Zimová, R. | Langrová, H.

Affiliations: IInd Department of Internal Medicine, Haematology, Medical Faculty, Charles University, Hradec Králové, Czech Republic | Department of Ophtalmology, Medical Faculty, Charles University, Hradec Králové, Czech Republic | Department of Geriatry and Metabolismus, Medical Faculty, Charles University, Hradec Králové, Czech Republic | Ist Department of Internal Medicine, Angiology, Medical Faculty, Charles University, Hradec Králové, Czech Republic | Institute of Immunology and Allergology, Medical Faculty, Charles University, Hradec Králové, Czech Republic | Department of Oncology and Radiotherapy, Medical Faculty, Charles University, Hradec Králové, Czech Republic

Note: [] Corresponding author. E-mail: [email protected].

Abstract: Rheological conditions basically influence tissue perfusion, oxygen and nutrient supply, tissue regeneration and in its consequence the course of pathological processes, especially in microcirculation and partially even in macrocirculation. Haemorheotherapy has shown to be successful in several indications (critical disorders in microcirculation) when other methods of therapy have failed. In this study we describe the changes of effectivity indicators in haemorheopheresis treatment and their clinical importance in cases of eye microcirculation, statoacoustic apparatus and disorders of the lower extremities. We treated with haemorheopheresis (separator Cobe.Spetra + Evaflux filter) 24 patients (16 patients with age related macular degeneration, 5 with critical peripheral arterial foot disease, and 3 with acute hearing loss). After the procedures α2-macroglobulin decreases by about 58%, fibrinogen by about 69%, IgM by about 61%, LDL-cholesterol by about 77%, apolipoprotein B by about 76% and lipoprotein(a) by about 63%. It corresponds with a decrease in blood and plasma viscosity and clinical improvement in the observed patients, i.e. visual improvement, acceleration of tissue defect healing and improvement in hearing. We noticed 7.1% clinically insignificant side-effects. The method of haemorheopheresis was safe. It led to improvement in patients' clinical condition in the above mentioned indications when other methods of treatment failed.

Keywords: Haemorheology, microcirculation, age related macular degeneration, diabetic foot, acute hearing loss

DOI: 10.3233/CH-2009-1184

Journal: Clinical Hemorheology and Microcirculation, vol. 42, no. 1, pp. 37-46, 2009