Affiliations: Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain | Department of Physiology, University of Valencia, Valencia, Spain | Department of Applied Linguistic, Polytechnic University of Valencia, Valencia, Spain | Genetic and Molecular Epidemiology Unit, School of Medicine, and CIBER Fisiopatología de la Obesidad y Nutrición CB06/03, University of Valencia, Spain
Note: [] Corresponding author: Amparo Vayá, MD, PhD, Hemorheology and Thrombosis Unit, Department of Clinical Pathology La Fe University Hospital Avda. Campanar 21, Valencia 46009, Spain. Tel.: +34 96 3862714; Fax: +34 96 1973109; E-mail: [email protected].
Abstract: Introduction: There is an association between rheological alterations and lower extremity deep vein thrombosis, although no research has been carried out regarding the possible influence of rheological alterations in the development of venous thrombosis in the upper limbs. Materials and methods: We have determined in 54 patients (23 male, 31 female; aged 35±11 years) with primary upper extremity deep vein thrombosis (UEDVT), and in a well matched control group of 87 subjects (41 male, 46 female; aged 36±12 years) the rheological profile (blood viscosity, plasma viscosity, fibrinogen, erythrocyte aggregation, erythrocyte deformability) along with plasma lipids (total cholesterol and triglycerides) and body mass index (BMI). Thrombophilic defects (antithrombin, protein C, protein S deficiencies, factor V Leiden, prothrombin G20210A mutation and antiphospholipid antibodies) were also determined. Results: No statistical differences were observed in any of the rheological parameters analyzed (p>0.05), as well as in plasma lipids and BMI (p>0.05) when cases and controls were compared. In investigating the associated factors, we found that more than 60% of events could be explained through effort (28%), thrombophilic defects (19%) and oral contraceptives (26%). Obesity and hyperlipidaemia were not associated with primary UEDVT. Conclusion: Hemorheological alterations do not seem to contribute from a pathogenic point of view to the development of thrombotic events in this infrequent venous location, which is in accordance both with the absence of cardiovascular risk factors and the high shear forces existing in the upper extremity.
Keywords: Hemorheology, upper-extremity deep vein thrombosis
