Are there two kinds of fibrinogen in diabetic plasma as suggested by a multivariate analysis?

Article type: Research Article

Authors: Schpitz-Droz, R. | Bucherer, C. | Ladjouzi, J. | Lacombe, C. | Lelievre, J. C.

Affiliations: Unité de Biorhéologie – Département de Biophysique, CHU Pitié-Salpêtrière, 91 Bd de l'Hôpital – 75013 Paris, France. Université Paris 6 - CNRS URA 343

Abstract: A set of experimental data was previously obtained from blood of healthy controls and insulin-treated diabetics clinically divided into three different groups: diabetics without retinopathy, diabetics with minimal retinopathy and diabetics with severe retinopathy (1). Results of the multivariate analysis of both biological and rheological data suggest the presence in diabetic plasma of two kinds of fibrinogen in contrast with normal plasma.

Keywords: multivariate analysis, diabetic plasma, fibrinogen

DOI: 10.3233/CH-1991-11516

Journal: Clinical Hemorheology and Microcirculation, vol. 11, no. 5, pp. 387-396, 1991