Confirmation of multiple sclerosis by red cell electrophoretic mobility

Article type: Research Article

Authors: Swank, Roy L.^; | Vaden, Ingeborg A. | Leckband, Anthony J.

Affiliations: Department of Neurology, Oregon Health Sciences University, Portland, OR 97201, USA

Note: [] Correspondence and reprint requests are to be addressed to Roy L. Swank

Abstract: The red cell electrophoretic mobility test by Field and Joyce was used as an adjunct in the diagnosis of 820 clinically acceptable cases of multiple sclerosis. In 90% of the cases the mobility of the red cells was consistent with MS (87% in early and 93% in later cases). In 5% of 109 normal subjects the mobility was consistent with MS. In 4 of 8 cases of Amyotrophic Lateral Sclerosis, in 1 of 7 cerebral infarctions, and in 1 irradiated tumor of 3 brain tumors, the mobility was consistent with MS. The related sensitivity of MRI and red cell electrophoretic mobility to MS was compared. The relative sensitivity of the MRI and Mobility tests for MS was compared.

Keywords: Electrophoretic mobility, Multiple sclerosis, Disseminated sclerosis, Red cell mobility tests, Magnetic Resonance Imaging (MRI)

DOI: 10.3233/CH-1991-11505

Journal: Clinical Hemorheology and Microcirculation, vol. 11, no. 5, pp. 281-293, 1991