Affiliations: Research Unit of Biomedical Engineering, West China | University of Medical Sciences, Chengdu, 610041, China
Abstract: In order to study the role of hemorheology in pathogenesis of acute hemorrhagic necrotizing pancreatitis (AHNP), forty four adult hybrid dogs were used and divided into 5 groups. Groups I and II were operation control (8 dogs) and acute interstitial pancreatitis group (8 dogs) respectively. Groups III–V suffered from AHNP by injection of sodium taurocholate in major pancreatic duct. Furthermore, groups IV and V were treated with Dextran 40 solution and Salvia Miltiorrhizae intravenous injection respectively. Arterial blood pressure and central venous pressure in all 5 groups did not exhibit significant changes before and after operation. Serum amylase and lipase level of groups III–V increased obviously after AHNP, but they decreased more rapidly in groups IV and V after treatment with drug than those in group III. Hemorheologic changes were measured with Low Shear 30 sinus. Plasma viscosity of all 5 groups had no evident changes before and after operation. There were no significant changes in hematocrit (HCT), apparent viscosities of whole blood at 0.512 sec−1 (η 0.512) and 51.2 sec−1 (η 51.2), aggregation index of RBC (AI), viscous component (η′) and elastic component (η″) of complex viscosity; and elastic modulus (G′) of whole blood in groups I and II had no significant alteration before and after operation. However, the parameters mentioned above in groups III–V increased significantly after AHNP had been induced by experiment. They decreased continuously after treatment with drug in groups IV and V. However, Salvia Miltiorrhizae injection in group V had better improvement in hemorheological alteration than DX40 in group IV did. The results suggested that abnormality of hemorheology was an important factor to introduce the disturbance of microcirculation of pancreas during AHNP and correction of hemorheological abnormality could improve symptoms of pancreatitis.
Keywords: Hemorheology, blood viscosity, viscoelasticity of blood, pancreatitis
