Effect of vasoactive drug MJ12880 [1-(4-(1-methyl-ethylothio)phenoxyl-3-Octylamino)-2-propanol hydrochloride] on in vitro blood viscosity of patients suffering from cancer or cardiovascular disorders

Article type: Research Article

Authors: Dintenfass, L.

Affiliations: Medical Research Department, Kanematsu Memorial Institute, Sydney Hospital; and Department of Medicine, University of Sydney, Sydney, Australia

Note: [] Accepted by: Editor G.V.F. Seaman

Abstract: Blood samples of 80 subjects were tested for blood viscosity, plasma viscosity, aggregation of red cells, and rigidity of cells in the presence and absence of drug MJ12880. There was a slight overall decrease of viscosity in the presence of the drug, although two specific responses were recognized: a positive response, in which there was a significant decrease in the viscosity factors, and a negative response in which there was a significant increase in the viscosity factors. A significant decrease of blood viscosity and a significant decrease in the rigidity of red cells has been observed after addition of drug in about half of blood samples obtained from cancer patients, and in one-third of blood samples from the cardiovascular and hypertensive patients. There was a significant difference in blood viscosity factors between potentially negative and potentially positive responders prior to the addition of drug. In general, samples of higher viscosity tended to respond by decreasing blood viscosity and rigidity of red cells; while samples of low viscosity tended to respond by increasing blood viscosity.

Keywords: blood viscosity, erythrocyte rigidity, drug MJ12880

DOI: 10.3233/CH-1981-1206

Journal: Clinical Hemorheology and Microcirculation, vol. 1, no. 2, pp. 153-165, 1981