Clinical Hemorheology and Microcirculation - Volume 8, issue 6

Authors: De-en, Hu | Jing-Chao, Ruan

Article Type: Research Article

Abstract: Hemorheological tests of 120 patients with nasopharyngeal carcinoma were performed, including whole blood viscosity, plasma viscosity, whole blood reducing viscosity, hematocrit, erythrocyte sedimentation rate and its equational coefficient K, erythroelectrophoresis, fibrinogen, triglyceride and cholesterol. There were statistically significant differences of all criteria (except cholesterol) between patients and controls. The numbers of abnormal parameters were correlated to the severity of the disease and prognosis. The numbers of abnormal parameters reduced after radiotherapy. There were higher incidences of recurrence and metastasis in patients with more abnormal parameters after radiotherapy. The relation between parameters of hemorheology and that of immunology were discussed.

Keywords: Radiotherapy, immunology, blood viscosity, plasma viscosity, early and advanced stage of cancer

DOI: 10.3233/CH-1988-8610

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 891-900, 1988

Authors: Bilto, Y.Y. | Ellory, J.C. | Player, M. | Stuart, J.

Article Type: Research Article

Abstract: Erythrocyte ATP was partially depleted by incubating normal human erythrocytes at 37°C for 24 hours. Incubation in the presence of 5 mmol/l oxpentifylline caused further depletion of ATP irrespective of whether membrane Na+ /K+ pump or Na+ /K+ /Cl− cotransport activities were inhibited and whether glycolysis was stimulated or inhibited. Similar depletion of erythrocyte ATP was found by incubating erythrocytes with either metabolite I of oxpentifylline, the rheologically active oxpentifylline analogue A81 3138, or the rheologically inactive natural methylxanthine theophylline. Partitioning of 14 C-oxpentifylline into the erythrocyte membrane was demonstrated but this did not increase membrane surface area …as tested by hypotonic stress. Thus the rheological action of oxpentifylline at 37°C, which is associated with inhibition of K+ efflux from erythrocytes, is a membrane-associated event and does not involve an increase in cell ATP content. Show more

Keywords: Rheology, Erythrocyte deformability, Oxpentifylline, Ion channels

DOI: 10.3233/CH-1988-8611

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 901-912, 1988

Authors: Agosti, R. | Clivati, A. | D’Ettorre, M. | Ferrarini, F. | Somazzi, R. | Longhini, E.

Article Type: Research Article

Abstract: We studied hematocrit, erythrocyte aggregation index and plasma fibrinogen level in 19 healthy subjects. We measured erythrocyte aggregation both on native blood and on washed erythrocytes resuspended in their own autologous plasma or serum. We found a significant negative linear correlation between hematocrit and the erythrocyte aggregation index on native blood whereas we found a significant negative polynomial (quadratic) correlation between hematocrit and erythrocyte aggregation on erythrocyte suspensions. Moreover we found a significant positive correlation between plasma fibrinogen levels and the erythrocyte aggregation index. Methodological and clinical aspects of these findings are discussed.

Keywords: erythrocyte aggregation, hematocrit, fibrinogen

DOI: 10.3233/CH-1988-8612

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 913-924, 1988

Authors: Caimi, Gregorio | Catania, Anna | Serra, Antonio | D’Asaro, Salvatrice | Lo Presti, Rosalia | Catalano, Concetta | Sarno, Antonio

Article Type: Research Article

Abstract: In a group of subjects with vascular atherosclerotic disease (VAD), we evaluated the erythrocyte membrane individual phospholipids using the two-dimensional thin layer chromatography. From the obtained preliminary data, it is evident that no individual phospholipids discriminate normals from subjects with VAD. The study of the relationships between individual phospholipids and red cell membrane fluidity (evaluated using a fluorescence technique and marking the red cells with pyrene) has shown a slight positive correlation between this microrheological parameter and the phosphatidylethanolamine content only.

Keywords: Vascular atherosclerotic disease, Red cell phospholipids, Membrane microviscosity

DOI: 10.3233/CH-1988-8613

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 925-928, 1988

Authors: Torricelli, P. | Palareti, G. | Poggi, M. | Faenza, S. | Petrini, F. | Zanoni, A. | Coccheri, S.

Article Type: Research Article

Abstract: In the first part of the study haemorheologic changes in 8 patients who received intra-operative autotransfusion were investigated during and after cardiopulmonary by-pass (CPB) surgery for aorto-coronary by-pass and compared with those obtained in comparable groups of bank blood transfused or non-transfused patients. No significant differences were found in blood viscosity at both shear rates tested, in plasma viscosity and in fibrinogen levels; the only variations were related to the different haematocrit levels. In the second part of the study the filterability of erythrocytes, after being processed for autotranfusion (“autotrans”), was determined in 10 patients submitted to CPB by means …of the St. George’s Filtrometer and compared with the filterability of red blood cells obtained by simultaneous venous blood sampling. Filterability was no different in “autotrans” and venous blood erythrocytes. In conclusion our data show that intra-operative autotransfusion during CPB surgery does not induce any measurable haemorheologic deterioration and seems therefore a safe procedure in relation to the flow properties of blood. Show more

Keywords: autotransfusion, intraoperative autotransfusion, blood viscosity, erythrocyte deformability, cardiopulmonary-by pass

DOI: 10.3233/CH-1988-8614

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 929-937, 1988

Authors: Caimi, Gregorio | Catania, Anna | D’Asaro, Salvatrice | Serra, Antonio | Catalano, Concetta | Bono, Antonino | Sarno, Antonio

Article Type: Research Article

Abstract: We evaluated red cell phospholipids and the relationships between these lipidic components and membrane microviscosity in a group of 12 diabetics of type 1, in a group of 16 diabetics of type 2 and in a group of 12 normal controls. From the obtained data, it is evident that no significant difference is present between normals and diabetics of type 1 regarding the individual phospholipids; between normals and diabetics of type 2 a significant difference regarding sphyngomyeline and phosphatidylcholine/sphyngomyeline ratio is evident. No statistical difference of the membrane microviscosity is present between normals and diabetics of type 1 and 2. …In normals and in diabetics of type 1 and 2 no relationship is evident between membrane microviscosity and individual phospholipids. Show more

Keywords: Diabetes mellitus, erythrocyte phospholipids, membrane microviscosity

DOI: 10.3233/CH-1988-8615

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 939-944, 1988

Authors: Hu, De-en | Ruan, Jing-chao | Wang, Pei-qing

Article Type: Research Article

Abstract: This study was carried out on 329 patients with nasopharyngeal carcinoma 120, thyroid cancer 27, esophagus carcinoma 10, primary hepatic cancer 67, stomach cancer 36, carcinoma of co.rdia 27, breast cancer 10 and lymphoma 32. The hemorheological tests were performed including whole blood viscosity, plasma viscosity, whole blood reduced v scosity, hematocrit, erythrocyte sedimentation rate and its equational coefficient K, erythroelectrophoresis, fibrinogen, triglyceride and cholesterol. It was shown that there was a significant elevation of fibrinogen in all types of cancer (except thyroid cancer) and significant elevation of red cell aggregation and increased plasma viscosity and whole blood reduced viscosity in …all type of cancer. These tests should be of diagnostic and prognostic value. Hemorheological changes in hepatic diseases (hepatitis, hepatocirrhosis and primary hepatic cancer) and gastric diseases (chronic superfical gastritis, chronic atrophic gastritis, ulcer and stomach. cancer) were observed respectively. Those tests, especially level of fibrinogen and K would be recognized as an adjuvant factor for evaluation the process and end-result of those diseases and to distinguish benignancy from malignancy. Show more

Keywords: Haemorheology, Cancer, Thyroid CA, Esophagus CA, Primary Hepatic CA, Stomach CA, CA of Cardia, Breast CA, Lymphoma, NP CA

DOI: 10.3233/CH-1988-8616

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 945-956, 1988

Authors: Brun, J.F. | Criqui, C. | Orsetti, A.

Article Type: Short Communication

Keywords: Rheology, Erythrocyte deformability, Diabetes

DOI: 10.3233/CH-1988-8617

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 957-960, 1988

Authors: Popp-Snijders, C. | Fonk, T.

Article Type: Letter

Keywords: Erythrocyte packing difference (EPD), centrifugal packing, hematocrit

DOI: 10.3233/CH-1988-8618

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 961-962, 1988

Authors: Chien, Shu | Skalak, Richard

Article Type: Announcement

DOI: 10.3233/CH-1988-8619

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 6, pp. 963-963, 1988