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Price: EUR 185.00Authors: Carlisi, Melania | Mancuso, Salvatrice | Lo Presti, Rosalia | Siragusa, Sergio | Caimi, Gregorio
Article Type: Research Article
Abstract: BACKGROUND: in this study, with a re-evaluation of the hemorheological determinants previously described in MGUS subjects and in MM patients, we have detected the calculated whole blood viscosity, according whether to the hematocrit and total plasma protein concentration (de Simone formula) or to the haematocrit and plasma fibrinogen level (Merrill formula), and a marker of the erythrocyte aggregation (albumin/fibrinogen level). METHODS: data were expressed as means±standard deviation. Student’s t test for unpaired data was used to compare MGUS subjects and MM patients. The correlation coefficient between mean erythrocyte aggregation (MEA) and hematocrit (Ht) was evaluated in MGUS, …MM and MGUS + MM groups using the Spearman test. RESULTS: the comparison between MGUS and MM shows that the measured blood viscosity and calculated blood viscosity based on hematocrit and total plasma protein, but not which estimated in relation to the hematocrit and plasma fibrinogen, differentiate the two groups. A difference between the two groups also regards the measured erythrocyte aggregation and its surrogate marker. In addition, the measured plasma viscosity at low shear rate (0.51 s–1 ) and, in particular, the ratio between plasma viscosity at low (0.51 s–1 ) and high (450 s–1 ) shear rates distinguish MGUS and MM. CONCLUSIONS: calculated blood viscosity (de Simone formula and other formulas) and the surrogate marker of erythrocyte aggregation disclose an alike trend with the corresponding hemorheological determinants obtained by using their direct measurement. Show more
Keywords: Calculated whole blood viscosity, measured whole blood viscosity, hematocrit, total plasma protein, albumin, fibrinogen
DOI: 10.3233/CH-211198
Citation: Clinical Hemorheology and Microcirculation, vol. 79, no. 3, pp. 475-483, 2021
Authors: Pantos, Constantinos | Apostolaki, Vassiliki | Kokkinos, Leonidas | Trikas, Athanassios | Mourouzis, Iordanis
Article Type: Research Article
Abstract: Sepsis and septic shock result in impaired microcirculation and red blood cell rheology which lead to tissue hypoxia and multi-organ failure. Early administration of triiodothyronine prevents tissue hypoxia in experimental sepsis. In this context, a clinical trial was initiated to test the efficacy of acute triiodothyronine administration to combat tissue hypoxia in critically ill COVID19 patients. Here, we provide preliminary data from interim analysis of this study showing a novel acute effect of triiodothyronine on erythrocyte sedimentation rate which may have an important therapeutic impact on red blood cell rheology and tissue hypoxia in sepsis and particular in COVID19 critical …illness. Trial registration: ClinicalTrials.gov, NCT04348513. Registered 16 April 2020, https://clinicaltrials.gov/ct2/show/NCT04348513 Show more
Keywords: Thyroid hormone, hypoxia, erythrocyte sedimentation rate, COVID19, microcirculation, hemorheology
DOI: 10.3233/CH-211215
Citation: Clinical Hemorheology and Microcirculation, vol. 79, no. 3, pp. 485-488, 2021
Article Type: Correction
DOI: 10.3233/CH-219902
Citation: Clinical Hemorheology and Microcirculation, vol. 79, no. 3, pp. 489-489, 2021
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