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Clinical Hemorheology and Microcirculation - Volume 73, issue 3

Purchase individual online access for 1 year to this journal.

Price: EUR 185.00
Impact Factor 2019: 1.642

Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.

The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.

Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.

The following professionals and institutions will benefit most from subscribing to Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.

Important new topics will increasingly claim more pages of Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.

Regulation of bone regeneration

Authors: Jung, Friedrich | Pietzsch, Jens

Article Type: Editorial

DOI: 10.3233/CH-199101

Citation: Clinical Hemorheology and Microcirculation, vol. 73, no. 3, pp. 379-380, 2019

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Adjuvant drug-assisted bone healing: Part I – Modulation of inflammation

Authors: Rothe, Rebecca | Schulze, Sabine | Neuber, Christin | Hauser, Sandra | Rammelt, Stefan | Pietzsch, Jens

Article Type: Research Article

Abstract:  Critical-size bone defects after compound fractures, infection, or tumor resection are challenging to treat. The same is true for fractures in patients with impaired bone healing due to metabolic diseases and cancer. Despite considerable progress over the last decade in surgical techniques, material design, and dedicated imaging approaches, these scenarios represent unsolved clinical problems. The high socioeconomic burden of such conditions justifies increasing interest in novel osteoinductive drugs for adjuvant therapeutic approaches. There is an increasing body of experimental and clinical literature on potentially promising effects of growth factors, anti-resorptive, and anabolic agents. The true clinical efficacy of these, however, … Show more

Keywords: Biomaterials, critical-size bone defects, cyclooxygenase-2, innate immunity, prostanoids, signaling, small molecules

DOI: 10.3233/CH-199102

Citation: Clinical Hemorheology and Microcirculation, vol. 73, no. 3, pp. 381-408, 2019

Price: EUR 27.50

Adjuvant drug-assisted bone healing: Part II – Modulation of angiogenesis

Authors: Rothe, Rebecca | Schulze, Sabine | Neuber, Christin | Hauser, Sandra | Rammelt, Stefan | Pietzsch, Jens

Article Type: Research Article

Abstract:  The treatment of critical-size bone defects following complicated fractures, infections or tumor resections is a major challenge. The same applies to fractures in patients with impaired bone healing due to systemic inflammatory and metabolic diseases. Despite considerable progress in development and establishment of new surgical techniques, design of bone graft substitutes and imaging techniques, these scenarios still represent unresolved clinical problems. However, the development of new active substances offers novel potential solutions for these issues. This work discusses therapeutic approaches that influence angiogenesis or hypoxic situations in healing bone and surrounding tissue. In particular, literature on sphingosine-1-phosphate receptor modulators and … Show more

Keywords: Critical-size bone defects, neovascularization, nitric oxide donors, signaling, small molecules, sphingosine-1-phosphate receptor

DOI: 10.3233/CH-199103

Citation: Clinical Hemorheology and Microcirculation, vol. 73, no. 3, pp. 409-438, 2019

Price: EUR 27.50

Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation

Authors: Rothe, Rebecca | Schulze, Sabine | Neuber, Christin | Hauser, Sandra | Rammelt, Stefan | Pietzsch, Jens

Article Type: Research Article

Abstract: In this third in a series of reviews on adjuvant drug-assisted bone healing, further approaches aiming at influencing the healing process are discussed. Local and systemic modulation of bone metabolism is pursued with use of a number of drugs with completely different indications, which are characterized by a pleiotropic spectrum of action. These include drugs used to treat lipid disorders (HMG-CoA reductase inhibitors), hypertension (ACE inhibitors), osteoporosis (bisphosphonates), cancer (proteasome inhibitors) and others. Potential applications to enhance bone healing are discussed.

Keywords: Bisphosphonates, bone metabolism, critical-size bone defects, small molecules, statins, strontium, Wnt signaling

DOI: 10.3233/CH-199104

Citation: Clinical Hemorheology and Microcirculation, vol. 73, no. 3, pp. 439-488, 2019

Price: EUR 27.50
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