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Price: EUR 185.00Authors: Melinda, Vass | Ágnes, Diószegi | Norbert, Németh | Viktória, Sógor | Sándor, Baráth | Eszter, Szalai | László, Módis | Soltész, Pál
Article Type: Research Article
Abstract: Rheopheresis is an extracorporal selective double-filtration procedure. In the first part of the treatment the blood is passes through the plasma filter, which separates blood cells from the plasma. Then the plasma flow to a second filter called MONET (Membranefiltration Optimised Novel Extracorporal Treatment). The MONET filter retains high molecular weight proteins such LDL, Lp(a), fibrinogen, α2 macroglobulin, vWF and IgM. Hereby the whole blood and plasma viscosity decrease, improves microcirculation, and has a positive effect on lipid profile as well. Accorging to ASFA recommendation rheopheresis is a first line treatment in age-related dry macular degeneration and in sudden …sensorineural hearing loss. There are other clinical situations in which rheopheresis has been used effectivly. But only few data are available and large clinical trials have not been done in these diseases. In this paper we describe a case history and laboratory findings of a patient who suffers from age related dry macular degeneration and was successfully treated by rheopheresis. Show more
Keywords: Rheopheresis, microcirculation, age-related dry macular degeneration, anti-inflammatory effect, haemorheological parameters
DOI: 10.3233/CH-168004
Citation: Clinical Hemorheology and Microcirculation, vol. 64, no. 4, pp. 977-987, 2016
Authors: Esteves, Rita | Freitas, Teresa | Teixeira, Pedro | Napoleão, Patrícia | Neves, Carlos | Saldanha, Carlota
Article Type: Research Article
Abstract: BACKGROUND: Glaucoma is an optic neuropathy associated with vascular dysregulation and increased intra-ocular pressure (IOP). Timolol is used as treatment for reducing IOP, by limiting aqueous humour production. Increased NOS expression as well as decreased levels of nitric oxide (NO) metabolites, and high activity of erythrocyte acetylcholinesterase (AChE) were observed in primary open angle glaucoma patients. OBJECTIVE: This ex vivo study aims to evaluate timolol effect in NO efflux and its derivatives in glaucoma patient’s erythrocytes. METHODS: Venous blood from 15 glaucoma patients was collected. Erythrocyte suspensions were incubated with the AChE modulators acetylcholine …(ACh) and timolol at 10 μM. Erythrocyte NO efflux and S-nitrosoglutathione (GSNO) concentration were measured. RESULTS: No significant differences were obtained in erythrocyte NO efflux and GSNO concentration in response to ACh or timolol when compared with the untreated erythrocytes of glaucoma patients. When comparing the same incubation conditions for erythrocyte suspensions between glaucoma patients and healthy subjects, those from glaucoma patients showed higher NO efflux in presence and absence of timolol, and higher values of GSNO in the presence of timolol. CONCLUSIONS: We demonstrated that erythrocytes from glaucoma patients have similar availability to release NO both in absence and presence of timolol, and have higher GSNO values in presence of timolol. Show more
Keywords: Glaucoma, erythocyte, nitric oxide, GSNO, ACh, timolol
DOI: 10.3233/CH-168049
Citation: Clinical Hemorheology and Microcirculation, vol. 64, no. 4, pp. 989-994, 2016
Article Type: Other
Citation: Clinical Hemorheology and Microcirculation, vol. 64, no. 4, pp. 995-1010, 2016
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