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Price: EUR 185.00Authors: Isbister, James B. | Harris, David C.H. | Ibels, Lloyd S.
Article Type: Research Article
Abstract: Azotaemia in patients with myeloma at the time of presentation is regarded as indicating a poor prognosis. Hypercalcaemia, hyperuricaemia, sepsis, nephrotoxic drugs, amyloid and plasma cell infiltration may be important in some cases, but intrarenal haemodynamics, glomerular filtration dynamics, tubular dysfunction and paraprotein nephrotoxicity may be more important. Immunoglobulin light chains which are freely filtered by the glomerulus have been shown to have a high correlation with the presence of renal insufficiency and there is evidence for these proteins being toxic to the renal tubular cells. With forced alkaline diuresis, with plasma exchange in some patients, it has been possible …to improve renal function. Experience with 14 patients with multiple myeloma in whom this has been achieved has given new insights into the pathophysiology and guidelines to the various modes of therapy. Show more
Keywords: Multiple Myeloma, Plasma Exchange, Renal Failure, Light Changes, Haemorheology
DOI: 10.3233/CH-1985-5410
Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 4, pp. 373-384, 1985
Article Type: Correction
DOI: 10.3233/CH-1985-5411
Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 4, pp. 385-385, 1985
Authors: Benner, Klaus-U | Nordt, Frank J.
Article Type: Abstract
DOI: 10.3233/CH-1985-5412
Citation: Clinical Hemorheology and Microcirculation, vol. 5, no. 4, pp. 387-392, 1985
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