Clinical Hemorheology and Microcirculation - Volume 5, issue 2
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Nineteen patients with the confirmed diagnosis of ankylosing spondylitis have been investigated for hemorheological abnormalities (serum, plasma and whole blood viscosities, hematocrit, red cell filterability and aggregation, fibrinogen, ESR). Compared to matched controls these variables showed significant deterioration in patients. The pathophysiological relevance of the findings would seem to merit further investigation.
Keywords: haemorheology, blood viscosity, plasma viscosity, red cell aggregation, red cell filterability, ankylosing spondylitis, rheumatic disease
Abstract: The haemorheological effect of a specific 5-hydroxy-tryptamine antagonist (ketanserin) was studied in 15 patients with severe ischaemic disease, given a continuous infusion for 7 days. The results were compared to a placebo infusion in 10 similar patients. The whole blood viscosity decreased significantly by 11–21% depending on the shear rate applied (0.7, 2.4 and 95 s−1 ) during active treatment. This viscosity decrease can be attributed to haemodilution, since the blood viscosity data corrected to a standard haematocrit did not show any significant change. The haemodilution may have been partly due to the very marked effect of ketanserin on physical…properties of white cells, manifested by a 53% decrease in the number of “clogging particles” 1n the blood. The red cell deformability index, determined as the transit time of red cells relative to the suspending medium, was also improved by ketanserin.
Abstract: Many of the large number of variables within the mammalian circulation are discussed. Certain measurements can be made directly in animals and also in man but are subject to inaccuracy of technique and must be analyzed statistically at all times. Inferential measurements which are drawn from the relationship between direct measurements must always have specific frames of reference within which they may be reasonably accurate but beyond which they become increasingly meaningless. Such frames of reference and their limits must always be tested and the results, again, estimated statistically and accepted only within the tested mathematical range. Qualitative inferences, of…course, can be drawn but are not subject to statistical evaluation and causality may remain problematical in any statistically significant measurement.
Abstract: Erythrocyte filtration, as measured by the initial-flow-rate Hemorheometre technique, showed a highly significant correlation (r = 0.603, P < 0.001) with even a small number of contaminating leucocytes (mean 0.08 × 109 /l, SEM 0.01) in 29 erythrocyte test suspensions. Failure to reduce leucocyte contamination to <0.025 × 109 /l caused falsely abnormal erythrocyte filtration values. Centrifugation failed to remove sufficient leucocytes from anaemic blood specimens but pre-filtration through Imugard IG500 cotton wool reduced leucocyte contamination to <0.025 × 109 /l in 73 of 74 blood samples. There was no evidence for selective cotton wool trapping of erythrocyte sub-populations to…an extent that affected rheological measurements obtained by the Hemorheometre, the Ektacytometer, or by adhesion of erythrocytes to cultured human vascular endothelium.
Abstract: The design of rheological studies is of critical importance for the demonstration of a true difference in erythrocyte deformability between patient and control groups. Principles that form the basis of good study design include an adequate number of patients, concurrent study of patients and matched controls, elimination of acute phase reactants, explanation of results in relation to known determinants of erythrocyte deformability, study of a representative blood sample, inclusion of a quality assurance programme, appropriate statistical analysis, and the use of a combination of rheological instruments that measure different aspects of erythrocyte deformability. These principles should routinely be applied when…designing, or evaluating, rheological studies.