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Price: EUR 185.00Authors: Gauthier, Chantal | Sèze-Goismier, Camille | Rozec, Bertrand
Article Type: Research Article
Abstract: The sympathetic system is central in the understanding of numerous physiological and physiopathological phenomena. During the last decade, the characterization of a new β-adrenoceptor subtype, β3 , in addition to β1 and β2 -adrenoceptor in the cardiovascular system has changed the view of the roles of the sympathetic system. In heart, β3 -adrenoceptor stimulation produce an opposite effect to that induced by β1 and β2 -adrenoceptors suggesting that in normal heart, the negative inotropic effect induced by the β3 -adrenergic stimulation might play a role of a “safety-valve” during intense adrenergic stimulation. In vessels, all β-adrenoceptors subtypes, β1 …, β2 and β3 , mediate a vasodilation. As β3 -adrenoceptors are activated at higher concentrations of catecholamines than β1 and β2 -adrenoceptors, they could play the roll of a receptor reserve. β3 -adrenoceptors are overexpressed in heart failure and hypertension and could constitute a new therapeutic target. In addition, the efficiency of some β-blockers such as nebivolol could result from an action on β3 -adrenoceptors. Show more
Keywords: Beta 3-adrenergic receptors, β-blocker, cardiovasular system, heart failure, hypertension
Citation: Clinical Hemorheology and Microcirculation, vol. 37, no. 1-2, pp. 193-204, 2007
Authors: Arribas, Silvia M. | González, José M. | Briones, Ana M. | Somoza, Beatriz | Daly, Craig J. | Vila, Elisabet | González, M. Carmen | McGrath, John C.
Article Type: Research Article
Abstract: Hypertension is associated with vascular structural alterations known as “vascular remodelling”, which initially are adaptive but in the long run, lead to vascular damage and loss of function. Despite decades of study, there is still modest information on the 3-dimensional (3D) arrangement of vascular cells and extracellular matrix (ECM) and how they change under pathological situations. To address this problem we developed a technique which combines fluorescence confocal microscopy, pressure myography and image analysis, “confocal myography”, which permits the study of intact resistance-sized vessels at cellular level and at physiological pressure. With the aid of this method, we have identified, …in arteries from hypertensive rats, abnormal orientation of endothelial, smooth muscle cells (SMC) and elastic fibres; elongation and denudation of endothelial cells, and adventitial hypercellularity. Confocal myography offers a new approach to the study of vascular remodelling in intact small arteries from a 3D point of view. Show more
Citation: Clinical Hemorheology and Microcirculation, vol. 37, no. 1-2, pp. 205-210, 2007
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