Clinical Hemorheology and Microcirculation - Volume 3, issue 6
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: A comparison has been made between reusable silver (Selas) and disposable polycarbonate (Nuclepore) membranes of 5 µm pore diameter as used for erythrocyte filtration (deformability) measurements in the initial-flow-rate (Hémorhéomètre) method. The two types of membrane showed similar sensitivity to sickle cells, erythrocytes containing Heinz bodies, glutaraldehyde-treated erythrocytes, and erythrocytes in hyperosmolar media. The silver membrane was, however, more sensitive to erythrocyte changes induced by heat or by storage under blood bank conditions. Conversely, it was insensitive to the presence of contaminating leucocytes in the test erythrocyte suspension. A high degree of precision was obtained with the reusable silver membrane…which has considerable potential for the development of quality assurance programmes in rheology.
Abstract: A comparison of filtration methods for the study of erythrocyte deformability has been made using an initial-flow-rate gravity filtration instrument (Hémorhéomètre) and both the initial (Pi) and final (Pf) pressures of positive-pressure filtration systems. Pf was the most sensitive filtration parameter for the detection of either a sub-population of hardened erythrocytes or a more uniform loss of deformability of the bulk cell population. This pilot study provides a basis for evaluation of commercial instruments and demonstrates the potential sensitivity, and improving precision, of positive-pressure systems.