Clinical Hemorheology and Microcirculation - Volume 2, issue 1-2
Purchase individual online access for 1 year to this journal.
Price: EUR 185.00
Impact Factor 2019: 1.642
Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Intracardiac blood flow dynamics was visualized by a newly developed pulsed Doppler flowmeter combined with an electronic phased-array echocardiograph, which allowed to locate sample sites precisely in the heart and great vessels. Intracardiac blood flow revealed a specific flow pattern to each sample portion and particularly a laminar mode in outflow and inflow tract of the left ventiricle in healthy subjects. In the mitral regurgitations observed was the systolic regurgitant flow into the left atrium, while the diastolic regurgitant flow in the left ve.ntricular outflow tract was observed in the aortic regurgitation. The present study indicates that the pulsed Doppler…technique is effective in noninvasively analyzing the intracardiac flow dynamics in human hearts.
Abstract: The blood velocity field and sites of occurrence of early atheroma are considered in arterial bifurcations in man. Evidence is increasing that these lesions occur preferentially where wall shear stress is low. Mechanisms are examined which might account for this correlation and also the influence of wall shear stress on the permeability of the arterial intima to macromolecules. Hypertension seemingly favours the development of atheroma, but the focal occurrence of lesions is not readily explained in terms of the arterial blood pressure. A widely held view is that atheroma results from damage to the endothelium and increased influx of lipoprotein,…and interaction of platelets with the damaged wall leading to smooth muscle cell replication and migration. Exposed subendothelium is, however, rarely seen, except over advanced lesions and a theory appears necessary to account for the observed findings in the absence of endothelial damage. Recent studies suggest that the media may offer a barrier to the drainage of material from the subendothelial space to the adventitia and that the transport properties of the media may be influenced by arterial blood pressure and medial smooth muscle tone.
Keywords: Arterial fluid mechanics, atherogenesis, blood velocity field, early atheroma, wall shear stress, absence of endothelial damage
Abstract: Atherosclerotic lesions and thrombus formation occur preferentially around bifurcations, curved segments and stenoses where flow is likely disturbed and vortices may form. Hence we have studied the detailed flow patterns, and the effects of the associated fluid mechanical stresses existing at such sites on the aggregation and wall adhesion of corpuscles using microrheological techniques and a newly developed method for making large arteries and veins transparent. The annular vortex formed downstream of a model stenosis was found to provide favorable conditions for spontaneous aggregation and enhanced adhesion of platelets onto the vessel wall. Similar flow patterns were observed in the…pockets of venous valves where venous thrombi are suspected to originate. Formation of standing vortices was also found in dog aortas at each branching site and in the sinus of the human internal-external carotid artery bifurcation under physiological flow conditions.