Clinical Hemorheology and Microcirculation - Volume 14, issue 2

Authors: Kent, P. | Williams, G. | Kester, R.C.

Article Type: Research Article

Abstract: Venous haematocrit, fibrinogen and red cell filterability were measured before and after one minute of acute hand vibration, in 8 normal subjects, 14 patients with primary Raynaud's phenomenon and 12 patients with vibration induced white finger. Acute hand vibration had no significant effect on haematocrit or fibrinogen levels. Red Cell Transit Time increased significantly in the primary Raynaud's group indicating a decrease in filterability in a large proportion of red cells. The number of clogging particles increased significantly in both the Primary Raynaud's group and the control group. Although the number of clogging particles increased in the VWF group, this …did not reach statistical significance. These results indicate that exposure to acute hand vibration causes a decrease in the filterability of red cells and this may be a contributory factor in the decrease in digital blood flow that occurs in response to acute vibration. Show more

Keywords: Vibration, haematocrit, fibrinogen, red cell filterability

DOI: 10.3233/CH-1994-14211

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 245-253, 1994

Authors: Boynard, M. | Ribier, F. | Guillet, R. | Driss, F. | Perrotin, P. | Gaudey, F. | Pautou, C. | Nalpas, B.

Article Type: Research Article

Abstract: To assess the possible influence of age, gender, cigarette smoking, menstrual cycle and oral contraceptives on red blood cell (RBC) deformability, cell transit parameters for one-hundred-ninety-four healthy adult subjects (seventy-nine males and one-hundred-fiveteen females) have been measured by filtration with the Cell Transit Analyser (CTA). The CTA provides the distribution of cell transit times of 5000 red blood cells, the mean transit time <τ> of the RBC population and different percentiles such as p50, p75, p90 and p95. First, correlations between <τ> and mean cell volume (MCV) were calculated for the entire population. Secondly, the influence of sex, age, cigarette …smoking, menstrual cycle and oral contraceptives on the RBC mean transit time was evaluated. For RBC with 80 fl < MCV < 98 fl, a very tight correlation between <τ> and MCV was found (r = 0.41; p < 0.001). No effect of age, cigarette smoking and oral contraceptives was found. Nevertheless, influence of sex and menstrual cycle were demonstrated. A significant increase of the CTA parameters measured in the female population with respect to the male population and during menstruation, preovulation and post-ovulation periods was observed. During ovulation, the CTA parameters are comparable to the same parameters in males. Show more

DOI: 10.3233/CH-1994-14212

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 255-262, 1994

Authors: Landgraf, Helmut | Schulte-Huermann, Detlef | Ehrly, Albrecht M.

Article Type: Research Article

Abstract: Tissue pO2 values (tibial anterior muscle), oxygen saturation, transcutaneous pO2 , arterial p02 , and rheological parameters were measured in 10 young (mean age 26,9 ± 0,9 years) as well as in 10 older (mean age 59,3 ± 5,9 years) apparently healthy volunteers during acute exposure to hypoxia according to a pressure altitude of approximately 8500 feet for 20 minutes. Hypoxia exposure was achieved by inspiration of an oxygen reduced gas mixture (116 mm Hg pO2 ). Average arterial pO2 and oxygen saturation decreased significantly in the young but not in the older volunteers. Tissue pO2 values …showed a marked and significant decrease in both groups (23.9 mm Hg to 12.8 mm Hg in the young and 20.8 mm Hg to 12.2 mm Hg in the older volunteers (medians)). Transcutaneous pO2 values also decreased significantly in both groups. The studied hemorheological parameters did not change significantly. The data show, that even a short exposure to moderately elevated pressure altitudes leads to a marked decrease in tissue oxygen tensions in young as well as in older healthy persons. Show more

Keywords: tissue oxygen pressure, hemorheology, altitude exposure, blood gases, transcutaneous oxygen pressure

DOI: 10.3233/CH-1994-14213

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 263-270, 1994

Authors: Kulkarni, M.V. | Puniyani, R.R.

Article Type: Research Article

Abstract: Freshly detected diabetic (maturity-onset) cases were studied for their hemorheological parameters before starting the treatment. The parameters studied were, whole blood viscosity, plasma viscosity, red cell rigidity, red cell aggregation, hematocrit and fibrinogen. All the parameters were significantly altered. Plasma viscosity, whole blood viscosity and red cell rigidity showed increase with very high level of significance (<0.005) as compared to that of normal controls. Hematocrit was significantly increased, Rheological parameters rise even if the fasting blood sugar is around 180 mg/100 ml which is in variance with Dintenfass and Davis (1). It may be due to the absence of any …antidiabetic treatment or since the disease is recently diagnosed the correction of impaired autoregulation has yet to start in the body. Diabetes starts affecting the body as soon as it gets diagnosed or may be even before that and hemorheological changes precede the microangiopathy that appears to show the cause effect relationship between hemorheological changes and microangiopathy respectively. Show more

Keywords: Maturity onset diabetes, hemorheology, microangiopathy, hyperglycemia

DOI: 10.3233/CH-1994-14214

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 271-278, 1994

Authors: Wen, Zong-yao | Tao, Zu-lai | Ma, Wei-yuan | Sun, Da-gong | Li, Tian-xun

Article Type: Short Communication

Keywords: RBC, Orientation, Deformation index, PBS, PVP, Neuraminidase, Ektacytometry

DOI: 10.3233/CH-1994-14215

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 279-283, 1994

Authors: Mchedlishvili, George

Article Type: Other

DOI: 10.3233/CH-1994-14216

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 285-286, 1994

Article Type: Abstract

DOI: 10.3233/CH-1994-14217

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 287-298, 1994

Article Type: Other

DOI: 10.3233/CH-1994-14218

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 299-300, 1994

Article Type: Other

DOI: 10.3233/CH-1994-14219

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 301-301, 1994

Article Type: Other

DOI: 10.3233/CH-1994-14220

Citation: Clinical Hemorheology and Microcirculation, vol. 14, no. 2, pp. 303-304, 1994