Clinical Hemorheology and Microcirculation - Volume 13, issue 6
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
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Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
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Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Erythrocyte deformability can be measured as filterability through a polycarbonate filter. To evaluate the influence of variations in filtration pressures the present study was performed as filtration of red cell suspensions with a pore size of 5 um at constant negative pressures of −10, −20, −30, −40 and −50 mm H2 O in the St. George's Filtrometer. Filtration parameters were expressed as passage time, flow rate, flow resistance, initial relative filtration rate (IrFR) , red cell transit time (RCTT) and clogging particles (CP). Passage time was decreased and flow rate was increased significantly at all filtration pressures compared to preceding…pressure level (p<0.001). In the pressure range −10 to −30 mm H2 O flow resistance decresed significantly (p<0.001) , but was almost constant in the range −30 to −50 mm H2 O. Also IrFR and RCTT showed a significantly greater change (p<0.001) when the pressure was increased from −10 to −20 mm H2 O compared to the same pressure change in the range −30 to −50 mm H2 O. CP varied more with pressure, but the greatest change was found in the range −10 to −20 mm H2 O. Variations of MCV within the normal range were associated with changes in passage time, flow resistance and CP in the pressure range −20 to −50 mm H2 O. It is concluded that the filtration pressure is an important factor in studies on blood cell filterability. For the St. George's Filtrometer the optimal pressure range seems to be −30 to −50 mm H2 O.
Keywords: Erythrocyte filterability, filtration test, stress factors, filtration pressure, wall shear stress, mean corpuscular volume, mean corpuscular hemoglobin concentration