Clinical Hemorheology and Microcirculation - Volume 12, issue 4
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Hemorheological and biochemical investigations were performed in 274 patients with hypertension. Whole blood viscosity was measured at 8 different shear rates and was categorized as per individual's blood group. Plasma viscosity, red cell rigidity, platelet aggregation, erythrocyte sedimentation rate, hematocrit, fibrinogen, and serum triglyceride were also studied. We have found that in case of blood group “O” increase in the whole blood viscosity was maximum while in blood group “B” it was minimum. There was no significant difference in the plasma viscosity among different blood group. It shows that red blood cell is one of the major contributing factor for…change in whole blood viscosity. This change in the whole blood viscosity among different blood groups could be due to difference in the charge density of different blood groups and/or particular blood group is more susceptible for change in the blood viscosity. When whole blood viscosity, plasma viscosity, red cell rigidity, fibrinogen and triglyceride parameters were compared with normal controls, they were found to be significantly elevated. There was no significant difference in hematocrit and platelet aggregation.
Abstract: The erythrocyte sedimentation rate (ESR) is a non-specific laboratory test that is widely used by clinicians in their assessment of a disease state. The phenomenon of erythrocyte sedimentation is largely dependent on the concentration of plasma proteins and their interactions with erythrocyte surfaces. The use of the ESR in sickle cell anemia is impaired by the abnormal deformability of sickled cells. In an attempt to bypass this phenomenon, a mixed erythrocyte sedimentation rate (M-ESR) has been developed. In the M-ESR the pathological erythrocytes of sickle cell anemia are substituted for normal erythrocytes. Although less than 60% of symptomatic patients with…sickle cell anemia had an elevated ESR, 100% had an elevated M-ESR.
Abstract: A three–week investigation was carried out on hemorheological and coagulative indices in rats exposed to carbon monoxide (CO). Results showed that in CO group, clotting times (tG″,tG′) were prolonged with lowered viscous modulus G″ and elastic modulus G′ of thrombus at thirty minute coagulation as well as platelet count (BP). However, hematocrit (Hct) and blood viscosity (BV) in this group were significantly increased. No difference in plasma viscosity (PV) was found between two groups. A correlation was established for the parameters, namely, G′=173.6+100.3PV−5.1Hct−6.6tG′. On the contrary, no alteration in Hct, G″, G′, platelet aggregation activity, clotting time of plasma was…found for blood exposed to CO in vitro. But it confirmed there was a strong negative correlation between Hct and G″ (r=−0.938), and G′ (r=−0.974) respectively. These results suggest that: (1) Carbon monoxide does not directly result in changes in thrombotic activity, but it can stimulate the growth of red blood cell by hypoxemia, (2) High Hct is responsible for the reduction of G″ and G′ in CO group.