Clinical Hemorheology and Microcirculation - Volume 10, issue 6
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: The role of blood fluidity in acute coronary syndromes is still unclear. Various studies have revealed hemorheological abnormalities in unstable angina and myocardial infarction. These hemorheological abnormalities are basically independent of risk factor profile and extent of coronary artery lesions. In unstable angina they are related to the risk of myocardial infarction. This suggests that the hemorheological abnormalities have some link to the pathogenesis of the disease. Due to alterations of the atherosclerotic plaque, acute coronary syndromes are characterized by continuous or intermittent impairment of flow. This leads to an intensive interaction of platelets and white blood cells with the…vessel wall causing release of interleukins 1 and 6. The resulting expression of acute phase reactants in hepatocytes induces an increase in plasma viscosity and red cell aggregation. Experimental evidence suggests that hemorheological abnormalities may in turn impede nutritional coronary flow. In addition, the increase in red cell aggregation promotes the interaction of other blood formed elements with the vessel wall, which is the prime event of ischemic microvascular injury. Therefore, hemorheological abnormalities in acute coronary syndromes may represent both, cause and consequence of the disease.