Clinical Hemorheology and Microcirculation - Volume 10, issue 5
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Piracetam has been reported to have a protective rheological effect on sickle cells. When sickle cells were subjected to cyclical oxygenation-deoxygenation for 15 hours in Ca2+ -containing buffer, there was a loss of cell filterability through pores of 5 µm diameter and an increase in mean cell haemoglobin concentration and percentage irreversibly sickled cells. These changes were consistent with entry of Ca2+ , activation of the Gardos channel in the sickle cell membrane, and loss of cell K+ and water. Piracetam at 100 mmol/l had a significant protective rheological effect. When sickle cells containing 86 Rb were loaded with…Ca2+ using the Ca2+ -ionophore A23187, however, the consequential efflux of K+ (86 Rb) through the Gardos channel was not inhibited by 10 or 100 mmol/l piracetam. The action of piracetam in preventing dehydration of sickle cells would not therefore seem to be due to inhibition of the Gardos channel.
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Abstract: Blood rheology measurements (whole blood viscosity, plasma viscosity, hematocrit and fibrinogen) and fibrinolytic and metabolic tests (plasma fibrinolytic activity, C-peptide, total cholesterol, triglycerides) were performed in 40 obese subjects before and after one year of hypocaloric diet. Our data show a slight decrease after weight loss of whole blood viscosity at 0.1 sec−1 but not at 1.3 and 94.5 sec−1 . Hypocaloric diet did not affect plasma viscosity, plasma fibrinogen or plasma fibrinolytic activity despite a significant lowering of body mass index and C-peptide. We conclude that in obesity there are metabolic, coagulation, fibrinolytic, and rheological changes…that persist after weight loss.
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Abstract: 30 patients undergoing elective aortic surgery had intraoperative autologous blood transfusion, 15 with the Solcotrans device and 15 with the Haemonetics Cell Saver system Markers of red cell damage and alteration of red cell parameters and biochemistry were studied. Using the St Georges Filtrometer, the filterability of preoperative red cells was compared to that of red cells that had undergone salvage. The indices of filtration measured were the red cell transit time (RCTT) and the number of clogging particles (CP). Various other parameters of red cell damage or known to affect red cell filterability were assessed. There was no…difference between the pre-operative and the salvaged red cell transit times with either autotransfusion device. However, for both devices, there were significantly more clogging particles in the salvaged samples than in the preoperative samples indicating the presence of a subpopulation of rigid cells. This is probably due to an increase in the MVC of damaged cells salvaged with the Solcotrans device, and a relative increase in the MCHC of damaged cells salvaged with the Cell Saver. A comparison of the results obtained for each device, shows that cell washing confers no advantage with respect to the filterability of autotransfused red cells, for differing reasons.
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