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Price: EUR 185.00Authors: Stuart, J. | Stone, P.C.W. | Nash, G.B. | Ellory, J.C.
Article Type: Research Article
Abstract: Piracetam has been reported to have a protective rheological effect on sickle cells. When sickle cells were subjected to cyclical oxygenation-deoxygenation for 15 hours in Ca2+ -containing buffer, there was a loss of cell filterability through pores of 5 µm diameter and an increase in mean cell haemoglobin concentration and percentage irreversibly sickled cells. These changes were consistent with entry of Ca2+ , activation of the Gardos channel in the sickle cell membrane, and loss of cell K+ and water. Piracetam at 100 mmol/l had a significant protective rheological effect. When sickle cells containing 86 Rb were loaded with …Ca2+ using the Ca2+ -ionophore A23187, however, the consequential efflux of K+ (86 Rb) through the Gardos channel was not inhibited by 10 or 100 mmol/l piracetam. The action of piracetam in preventing dehydration of sickle cells would not therefore seem to be due to inhibition of the Gardos channel. Show more
Keywords: Rheology, erythrocyte deformability, sickle cell anemia
DOI: 10.3233/CH-1990-10510
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 5, pp. 535-540, 1990
Authors: Craveri, A. | Tornaghi, G. | Paganardi, L. | Ranieri, R. | Giavardi, L.
Article Type: Research Article
Abstract: Blood rheology measurements (whole blood viscosity, plasma viscosity, hematocrit and fibrinogen) and fibrinolytic and metabolic tests (plasma fibrinolytic activity, C-peptide, total cholesterol, triglycerides) were performed in 40 obese subjects before and after one year of hypocaloric diet. Our data show a slight decrease after weight loss of whole blood viscosity at 0.1 sec−1 but not at 1.3 and 94.5 sec−1 . Hypocaloric diet did not affect plasma viscosity, plasma fibrinogen or plasma fibrinolytic activity despite a significant lowering of body mass index and C-peptide. We conclude that in obesity there are metabolic, coagulation, fibrinolytic, and rheological changes …that persist after weight loss. Show more
Keywords: Weight loss, Hemorheology, Fibrinolysis, Obesity
DOI: 10.3233/CH-1990-10511
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 5, pp. 541-546, 1990
Authors: Kent, P.J. | Williams, G. | Kester, R.C.
Article Type: Research Article
Abstract: 30 patients undergoing elective aortic surgery had intraoperative autologous blood transfusion, 15 with the Solcotrans device and 15 with the Haemonetics Cell Saver system Markers of red cell damage and alteration of red cell parameters and biochemistry were studied. Using the St Georges Filtrometer, the filterability of preoperative red cells was compared to that of red cells that had undergone salvage. The indices of filtration measured were the red cell transit time (RCTT) and the number of clogging particles (CP). Various other parameters of red cell damage or known to affect red cell filterability were assessed. There was no …difference between the pre-operative and the salvaged red cell transit times with either autotransfusion device. However, for both devices, there were significantly more clogging particles in the salvaged samples than in the preoperative samples indicating the presence of a subpopulation of rigid cells. This is probably due to an increase in the MVC of damaged cells salvaged with the Solcotrans device, and a relative increase in the MCHC of damaged cells salvaged with the Cell Saver. A comparison of the results obtained for each device, shows that cell washing confers no advantage with respect to the filterability of autotransfused red cells, for differing reasons. Show more
Keywords: autotransfusion, intraoperative autotransfusion, blood filtration
DOI: 10.3233/CH-1990-10512
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 5, pp. 547-555, 1990
Authors: Khodabandehlou, T. | Le Devehat, C.
Article Type: Short Communication
Keywords: Red Cell Aggregation, Diabetes Mellitus
DOI: 10.3233/CH-1990-10513
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 5, pp. 557-560, 1990
Authors: Judkiewicz, L. | Ciszewski, R. | Bartosz, G.
Article Type: Letter
Keywords: Erythrocyte, Mechanical properties, Deformability, Diabetes
DOI: 10.3233/CH-1990-10514
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 5, pp. 561-563, 1990
Authors: Isogai, Y.
Article Type: Announcement
DOI: 10.3233/CH-1990-10515
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 5, pp. 565-565, 1990
Article Type: Other
DOI: 10.3233/CH-1990-10516
Citation: Clinical Hemorheology and Microcirculation, vol. 10, no. 5, pp. 567-567, 1990
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