Clinical Hemorheology and Microcirculation - Volume 10, issue 4
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Macro and micro-hemorheological analyses on thirteen kinds of cardiovascular and related diseases and healthy young and old controls, 1.102 cases, were carried out together with analyses of hemorheology-related factors. Whole blood viscosity at shear rate of 94.5 and 0.376 s−1 and plasma viscosity at shear rate of 94.5s−1 was measured respectively by Low Shear-30. Whole blood at both shear rates and plasma viscosity in valvular diseases showed significant decrease and those of all the other diseases did not show significant change compared to those of young and old control. Whole blood Passage time measured through Nuclepore membrane with…pore size of 5 µm were prolonged significantly in all these diseases with except of valvular diseases. Fibrinogen revealed significant increase in all these diseases. Macrohemorheology presented by whole blood and plasma viscosity in cardiovascular diseases and old control except valvular diseases showed no significant changes, while microhemorheology presented by whole blood passage time of them demonstrated significant abnormalities. The direction of change in macro and microhemorheology in valvular disease was quite different from other that observed in cardiovascular diseases.
Abstract: We evaluated the microrheological determinants and the red cell membrane individual membrane phospholipids in subjects with VAD. Our study included four groups of patients. In the first group, we evaluated the membrane lipid fluidity using the ghosts marked with DPH. In the second group, the erythrocyte membrane fluidity was employed marking intact red cells with pyrene. In the third group, the membrane fluidity transverse gradient was evaluated marking intact red cells with fatty acid fluorescent probes: 2-AP, 6-AS, 9-AS, 12-AS. In the fourth group we evaluated the red cell membrane phospholipids and the Iex/Im ratio. Examining the first group, it…is evident that the fluorescence polarization degree does not discriminate normals from this group. Examining the second group, it is evident that the Iex/Im ratio distinguishes normals from this group. Examining the third group, it is evident that the degree of polarization obtained with each fatty acid fluorescent probe does not distinguish normals from this group. Examining the fourth group, it is evident that no significant difference is present between normals and this group regarding erythrocyte individual phospholipids; a slight significant correlation is evident only between the Iex/Im ratio and phosphatidylethanolamine.