Clinical Hemorheology and Microcirculation - Volume 10, issue 2
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: While the mechanism of platelet and more recently leukocyte interactions with vessel walls in heart disease have been extensively studied, the phenomenon of red cell binding to endothelium in this condition has not been previously described. To test the hypothesis that erythrocyte endothelial cell adherence may be an important component of flow disturbance in patients with myocardial injury venous blood from 31 patients admitted with chest pain suggestive of myocardial infarction or ischemia was compared to blood from acutely ill patients without ischemic injury and normal controls. Red cells separated from white cells and platelets were allowed to adhere to…endothelial cells grown in culture from human umbilical cord veins. Shear force ranging from 0.1 to 55 dynes/cm2 was applied by calibrated fluid flow through a micropipette. Direct visualization by microscope, allowed precise measurement of the stress required to separate individual red cells from the endothelial cell monolayer. In those patients who had documented ischemic damage adherence ranged from 1.3% of red blood cells at 20 dynes/cm2 (the approximate maximum shear stress in venules) to 0.01% RBC at 55 dynes/cm2 , (maximum shear stress in arterioles). In control samples and in hospital patients without documented ischemia, 0.55% cells adhered at 20 dynes/cm2 and less than 0.01% adhered at 55 dynes/cm2 . Autologous plasma increased the percent of maximally adherent cells to 21.9% in patients with unstable angina compared to 1.5% in patients without documented ischemia. Some adherent red cells that separated from the endothelium while under fluid flow conditions, immediately reattached to adjacent endothelial cells, implying that only brief contact is required for adherence to occur. We conclude that in areas of the microcirculation where erythrocyte-endothelial cell contact occurs, abnormal adherence may compromise blood flow and contribute to ischemic injury in some patients with ischemic heart disease.