Quantitative study of fibrinogen molecules’ contribution to the inter‐red cells connections in selected clinical groups of stroke patients

Article type: Research Article

Authors: Kowal, Piotr^;

Affiliations: Department of Neurology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland

Note: [] Address for correspondence: P. Kowal, M.D., Department of Neurology, Karol Marcinkowski University of Medical Sciences, Przybyszewskiego 49, 60‐355 Poznań, Poland.

Abstract: In a group of 36 patients with acute ischemic stroke, a study of the influence of arterial hypertension on the red cells and fibrinogen interaction was carried out by the aspect of fibrinogen molecules’ contribution to this phenomenon, respecting the role of other plasma biochemical factors. Patients were divided into two clinical groups: with and without arterial hypertension. In the blood samples with stable haematocrit ratio the following rheological properties were estimated: plasma viscosity, yield shear stress (YSS), fibrinogen level and parameter R (the difference between two measurements of fibrinogen concentration). Also measured were the levels of albumin, IgG, IgA, IgM, cholesterol, HDL and LDL. The value of parameter R in patients with arterial hypertension was lower than in the group without accompanying disease (statistical significance was indicated for 80 and 60% of plasma dilution). The first group of patients was also characterized by a significant increase of IgA level (in comparison with the control group), whereas the red cells and fibrinogen interaction measured as a value of YSS was similar in both analysed clinical groups. This study indicated a specific character of some hemorheological changes in relation to a certain vascular pathology.

Journal: Clinical Hemorheology and Microcirculation, vol. 18, no. 1, pp. 37-41, 1998