Pharmacological modulation of erythrocyte adhesion to endothelium in diabetes mellitus

Issue title: Red Cell Aggregation. Proceedings of the Second International Symposium. Paris, France, January 1988

Guest editors: J.F. Stoltz

Article type: Research Article

Authors: Wautier, J.L. | Wautier, M.P. | Guillausseau, P.J.

Affiliations: U.150 INSERM, U.334 CNRS, Hôpital Lariboisière 2, rue Ambroise Paré, 75010 Paris, France

Note: [] Accepted by: Editor J.F. Stolz

Abstract: Erythrocyte adhesion to endothelial cells was measured using human umbilical vein endothelial cells in culture and a radiometric method. Erythrocyte adhesion was found to be increased in a group of twelve diabetics as compared to normal. The increase in adhesion was statistically significant (p<0.001) and was modified by the addition of Troxerutine in vitro. Troxerutine at a concentration of 10−6M impaired the abnormal erythrocyte adhesion observed in diabetics but from these results we cannot extrapolate the in vivo effect of the drug.

Keywords: Endothelium, Erythrocyte, Pharmacology, Adhesion, Diabetes

DOI: 10.3233/CH-1989-9516

Journal: Clinical Hemorheology and Microcirculation, vol. 9, no. 5, pp. 855-860, 1989